もう行く?新しい膀胱デバイスが教えてくれる(Gotta go? New bladder device lets you know)

ad

2024-03-25 ノースウェスタン大学

もう行く?新しい膀胱デバイスが教えてくれる(Gotta go? New bladder device lets you know)
To monitor the bladder, the new device comprises multiple sensors, which work together to measure one simple parameter: strain. As the bladder fills, it expands. The fuller the bladder becomes, the more it stretches. This stretching pulls on the elastic-like device to signal strain.

ノースウェスタン大学の研究者は、柔軟でバッテリーフリーの新しいインプラントとそれに連動したスマートフォンアプリを開発し、膀胱の満腹度をリアルタイムでモニタリングできるようにしました。この技術は、脊髄損傷や膀胱がんなどの障害を持つ人々にとって有益であり、遠隔地から患者をモニタリングし、治療を迅速に行うことができます。さらに、将来的にはスマートフォンから尿意を誘発する機能も追加される見込みです。

<関連情報>

手術後の膀胱機能をモニターするためのワイヤレス埋め込み型バイオエレクトロニクスシステム A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery

Jihye Kim, Matthew I. Bury, Kyeongha Kwon, +24, and John A. Rogers
Proceedings of the National Academy of Sciences  Published:March 28, 2024
DOI:https://doi.org/10.1073/pnas.2400868121

Significance

Increasing interest in personalized medical systems motivates the development of bioelectronic implants for sensing physiological functions. Such implants could potentially provide physicians with real-time information to guide treatment and management strategies regarding tissue disease or trauma. Within the context of urinary bladder dysfunction, internal pressures can be indicative of bladder recovery following surgical interventions. This study reports a fully implantable system for quantitative measurements of the temporal dynamics of bladder filling and voiding via wireless telemetry, employing stretchable strain gauges in both permanent and bioresorbable forms. Validation studies in rodent and nonhuman primate models demonstrate the potential for this system to provide personalized treatment and rehabilitation strategies to human counterparts.

Abstract

Partial cystectomy procedures for urinary bladder–related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.

医療・健康
ad
ad
Follow
ad
タイトルとURLをコピーしました