2024-11-28 スイス連邦工科大学ローザンヌ校(EPFL)
<関連情報>
- https://actu.epfl.ch/news/brain-stimulation-effectiveness-tied-to-learning-a/
- https://www.nature.com/articles/s41539-024-00278-y
脳刺激の効果を決めるのは、年齢ではなく生まれつきの学習能力 Native learning ability and not age determines the effects of brain stimulation
Pablo Maceira-Elvira,Traian Popa,Anne-Christine Schmid,Andéol Cadic-Melchior,Henning Müller,Roger Schaer,Leonardo G. Cohen & Friedhelm C. Hummel
npj Science of Learning Published:27 November 2024
DOI:https://doi.org/10.1038/s41539-024-00278-y
Abstract
Healthy aging often entails a decline in cognitive and motor functions, affecting independence and quality of life in older adults. Brain stimulation shows potential to enhance these functions, but studies show variable effects. Previous studies have tried to identify responders and non-responders through correlations between behavioral change and baseline parameters, but results lack generalization to independent cohorts. We propose a method to predict an individual’s likelihood of benefiting from stimulation, based on baseline performance of a sequential motor task. Our results show that individuals with less efficient learning mechanisms benefit from stimulation, while those with optimal learning strategies experience none or even detrimental effects. This differential effect, first identified in a public dataset and replicated here in an independent cohort, was linked to one’s ability to integrate task-relevant information and not age. This study constitutes a further step towards personalized clinical-translational interventions based on brain stimulation.
