2025-04-23 中国科学院(CAS)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202504/t20250423_1041783.shtml
- https://www.sciencedirect.com/science/article/abs/pii/S2212429225007382
食用蒙古肝茶(Swertia diluta)由来成分ベリジフォリンは、高脂肪食誘発肥満マウスにおいて腸内細菌叢と胆汁酸代謝を制御することにより脂質代謝を促進する Bellidifolin, a constituent from edible Mongolic Liver Tea (Swertia diluta), promotes lipid metabolism by regulating intestinal microbiota and bile acid metabolism in mice during high fat diet-induced obesity
Aikebaier Jumai, Shaohua Chen, Yaodan Wu, Fen Liu, Bailin Li, Baojun Zhu, Liyun Zhao, Kanglun Liu, Qingzhong Zhang, Sheng-Xiang Qiu
Food Bioscience Available online: 8 April 2025
DOI:https://doi.org/10.1016/j.fbio.2025.106562
Graphical abstract
Highlights
- Swertia diluta contains rich xanthones, with bellidifolin (BEL) as a major compound.
- BEL effectively ameliorates physiological and biochemical parameters in obese mice.
- BEL modulates gut microbiota linked to lipid metabolism in high-fat diet conditions.
- BEL enhances bile acid metabolism, promoting improved lipid regulation.
Abstract
Metabolic disorders like obesity and dyslipidemia are largely driven by high-fat diets (HFD), often with limited efficacy from current dietary interventions. This study investigates Swertia diluta, an edible potherb, for its potential hepatic and metabolic benefits. Using HPLC-MS/MS, 25 xanthone compounds were identified, with network pharmacology analysis indicating their relevance to lipid metabolism and atherosclerosis. Notably, bellidifolin (BEL) was isolated from this plant and studied in 12-week HFD-induced obesity model (HFD feeding for 12 weeks; BEL intervention from weeks 9–12), demonstrating significant improvements in lipid profiles and body weight reduction in male C57BL/6J mice. BEL also altered gut microbiota by reducing Firmicutes, Lactobacillaceae, and Clostridiaceae abundance. Additionally, BEL enhanced bile acid biosynthesis and excretion, further improving lipid metabolism. These findings suggest BEL from Swertia diluta as a promising natural agent for weight management and enhanced lipid metabolism through gut microbiota and bile acid modulation in HFD conditions.
