音が感情に与える影響:中脳回路による解明(ZJU scientist reveals how noise triggers negative emotions via midbrain circuit)

2025-05-21 浙江大学 (ZJU)

<関連情報>

• https://www.zju.edu.cn/english/2025/0521/c19573a3053831/page.htm
• https://www.nature.com/articles/s41467-025-59956-z

ノイズによる負の価値コーディングの中脳回路メカニズム A midbrain circuit mechanism for noise-induced negative valence coding

Siyao Zhou,Yuebin Zhu,Ana Du,Shuai Niu,Yonglan Du,Yan Yang,Wenqiang Chen,Siyu Du,Li Sun,Yijun Liu,Hangjun Wu,Huifang Lou,Xiao-Ming Li,Shumin Duan & Hongbin Yang
Nature Communications  Published:17 May 2025
DOI:https://doi.org/10.1038/s41467-025-59956-z

Abstract

Unpleasant sounds elicit a range of negative emotional reactions, yet the underlying neural mechanisms remain largely unknown. Here we show that glutamatergic neurons in the central inferior colliculus (CIC^glu) relay noise information to GABAergic neurons in the ventral tegmental area (VTA^GABA) via the cuneiform nucleus (CnF), encoding negative emotions in mice. In contrast, the CIC^glu→medial geniculate (MG) canonical auditory pathway processes salient stimuli. By combining viral tracing, calcium imaging, and optrode recording, we demonstrate that the CnF acts downstream of CIC^glu to convey negative valence to the mesolimbic dopamine system by activating VTA^GABA neurons. Optogenetic or chemogenetic inhibition of any connection within the CIC^glu→CnF^glu → VTA^GABA circuit, or direct excitation of the mesolimbic dopamine (DA) system is sufficient to alleviate noise-induced negative emotion perception. Our findings highlight the significance of the CIC^glu→CnF^glu → VTA^GABA circuit in coping with acoustic stressors.