2025-06-10 カロリンスカ研究所(KI)
<関連情報>
- https://news.ki.se/cervical-cancer-affects-both-the-mental-health-and-finances-of-families
- https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djaf129/8158658
子宮頸癌女性、その子供および共同親における精神障害と社会経済的転帰 Mental disorders and socioeconomic outcomes in women with cervical cancer, their children and co-parents
Jiangrong Wang, PhD , Stina Salomonsson, MD, PhD , Demet Sönmez, PhD , Sara Nordqvist Kleppe, MSc , Adina L Feldman, PhD , Marcus Sven Andersson, PhD , Goran Bencina, PhD , Fang Fang, PhD , Karin Sundström, MD PhD
JNCI: Journal of the National Cancer Institute Published:10 June 2025
DOI:https://doi.org/10.1093/jnci/djaf129
Abstract
Background
Cervical cancer often affects women who are in the middle of life and may carry substantial mental and socioeconomic impact also on families. We performed a generation-spanning study to elucidate this burden
Methods
We utilized nationwide registers during 1991-2018 in Sweden to perform two matched cohort studies based on a source population of more than 5 million women. The individual sub-study included 6060 cases of cervical cancer diagnosed during 2006-2018 and 5 population comparators individually matched to each case by age, birth year and region (n = 30300). The family sub-study included 9332 cases of cervical cancer diagnosed during 1991-2016 and 45,674 matched population comparators and all their children and co-parents.
Results
We found an increased risk for mental disorders in cases compared to comparators, particularly during the first two years post-diagnosis (HR = 3.74, 95% CI = 3.45-4.06). Socioeconomic status changed negatively in cases after their diagnosis a decreased income and increased need for financial aid appeared within 2 years whereas unemployment escalated from two years after cancer diagnosis. We further found an increased risk of mental disorders in both children and co-parents of the cases, compared to the children and co-parents of the comparators.
Furthermore, we observed negative socioeconomic trajectories in the co-parents and lower educational attainment in the children of the cases, especially if the case had died of her cancer.
Conclusions
Women with cervical cancer, and their close family members, display increased risk of negative mental health and socioeconomic outcomes after diagnosis. The lower educational attainment in children appears particularly worrying.
