2025-12-10 韓国基礎科学研究院(IBS)
Figure 1. Mechanically transformable and imperceptible hydrogel-elastomer adhesive bilayer (THIN) transistor based on an ion-electron conducting nanomembrane for bio-signal amplification
The IBS Center for Neuroscience Imaging has developed a free-standing ion-electron conducting nanomembrane (THIN) that retains structural integrity without external support. When implemented as an organic electrochemical transistor (OECT), the THIN device adapts conformally to curved biological tissues by absorbing bodily fluids and enables real-time on-site amplification of subtle bio-signals for precise in vivo monitoring.
<関連情報>
- https://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do?nttId=26440&pageIndex=1&searchCnd=&searchWrd=
- https://www.nature.com/articles/s41565-025-02031-x
ソフトバイオエレクトロニクスのためのハイドロゲル-エラストマーベースの導電性ナノ膜 Hydrogel–elastomer-based conductive nanomembranes for soft bioelectronics
Hyunjin Jung,Daeyeon Lee,Kyoungryong Kim,Heewon Choi,Soojung An,Youngwan Lee,Sungjun Lee,Jiyong Yoon,Duhwan Seong,Yewon Kim,Jaepyo Jang,Subin Jin,Sumin Kim,Jeungeun Kum,Hyeok Kim,Sang Min Won,Hyungmin Kim,Seung-Pyo Lee,Hyung-Seop Han,Mikyung Shin,BongSoo Kim & Donghee Son
Nature Nanotechnology Published:10 December 2025
DOI:https://doi.org/10.1038/s41565-025-02031-x
Abstract
Conformal integration of electronics with soft, irregular organ topologies remains challenging, as tissue-like platforms with bulky dimensions ranging from a few millimetres to several hundred micrometres result in incomplete signal acquisition and chronic tissue compression. Although ultrathin nanoscale devices have recently been developed to address these challenges, they involve complex and delicate handling processes that limit their practical use and compromise their intrinsic performance. Here we present the development of a transformable and imperceptible hydrogel–elastomer adhesive bilayer based on ionic–electronic conductive nanomembranes (THIN) with a thickness of 350 nm. This approach leverages the amphiphilic properties and the combination of a hydrophilic tissue-adhesive hydrogel and a hydrophobic semiconducting elastomer. Dynamic bonding interactions at a heterogeneous interface, formed through a spin-coating process using orthogonal solvents, facilitate full compatibility with microfabrication. THIN exhibits an instantaneous rigid-to-soft phase transformation, transitioning from a hardness of 1.35 to 0.035 GPa and a stiffness of 0.16 to 9.08 × 10-5 GPa μm4, enabling facile handling when dried. On hydration, THIN achieves complete conformal contact with diverse surfaces, including those with low bending radii, along with rapid spontaneous adhesiveness. To demonstrate the unique electrical and mechanical characteristics, THIN was integrated into the active channel of an organic electrochemical transistor with a high µC* (µ, charge-carrier mobility; C*, volumetric capacitance). The resulting THIN-OECT exhibited an exceptional strain-insensitive ion–electron conduction performance, facilitating imperceptible tissue interfacing and precise biosignal monitoring through transformable phase changes.
