2024-10-31 カリフォルニア大学バークレー校(UCB)
<関連情報>
- https://newsroom.haas.berkeley.edu/research/exposure-to-sugar-restrictions-in-utero-and-early-childhood-reduces-risk-of-chronic-disease-study-finds/
- https://www.science.org/doi/10.1126/science.adn5421
生後1000日間の砂糖制限への曝露は慢性疾患から保護される Exposure to sugar rationing in the first 1000 days of life protected against chronic disease
Tadeja Gracner, Claire Boone, and Paul J. Gertler
Science Published:31 Oct 2024
Abstract
We examined the impact of sugar exposure within 1000 days since conception on diabetes and hypertension, leveraging quasi-experimental variation from the end of the United Kingdom’s sugar rationing in September 1953. Rationing restricted sugar intake to levels within current dietary guidelines, yet consumption nearly doubled immediately post-rationing. Using an event study design with UK Biobank data comparing adults conceived just before or after rationing ended, we found that early-life rationing reduced diabetes and hypertension risk by about 35% and 20%, respectively, and delayed disease onset by 4 and 2 years. Protection was evident with in-utero exposure and increased with postnatal sugar restriction, especially after six months when solid foods likely began. In-utero sugar rationing alone accounted for about one third of the risk reduction.
