LED光と錫ナノ粒子を用いた新たながん治療法(LED Light Blasts Cancer Cells and Spares Healthy Ones)

2025-10-09 テキサス大学オースチン校 (UT Austin)

The researchers’ custom near-infrared LED heating system activates SnOx nanoflakes that heat and neutralize cancer cells (green: live cells; red: cells killed by photothermal therapy).

<関連情報>

• https://news.utexas.edu/2025/10/09/led-light-blasts-cancer-cells-and-spares-healthy-ones/
• https://pubs.acs.org/doi/10.1021/acsnano.5c03135

電気化学的に酸化されたSnS 2粉末から合成された強化近赤外線光熱療法剤としてのSnOxナノフレーク SnOx Nanoflakes as Enhanced Near-Infrared Photothermal Therapy Agents Synthesized from Electrochemically Oxidized SnS2 Powders

Hui-Ping Chang,Filipa A. L. S. Silva,Eva Nance,José R. Fernandes,Susana G. Santos,Fernão D. Magalhães,Artur M. Pinto,and Jean Anne C. Incorvia
ACS Nano  Published: September 16, 2025
DOI:https://doi.org/10.1021/acsnano.5c03135

Abstract

Near-infrared (NIR) photothermal therapy (PTT) using nanomaterials is a promising strategy for selective cancer treatment. We report two tin-based two-dimensional (2D) nanoflakes─defective SnS₂ (SnS_2–x) and mixed-phase SnO_x─synthesized via top-down ultrasonication and electrochemical exfoliation with oxidation, respectively. Both nanoflakes have thicknesses below 20 nm, and their lateral sizes (<400 nm) were confirmed by AFM, DLS, atomic force microscopy, dynamic light scattering, and transmission electron microscopy (TEM). Despite a similar optical band gap (∼1.89 eV), SnO₂ nanoflakes display a significantly enhanced NIR photothermal performance under 810 nm light emitting diode (LED) irradiation. A 3 mg/mL SnO_x dispersion increases in temperature by ∼19 °C after 30 min, and a 0.25 mg/mL sample achieves a photothermal conversion efficiency of 93%. X-ray photoelectron spectroscopy and TEM analyses show that SnO_x consists of interconnected SnO and SnO₂ nanocrystals (<5 nm), which promote nonradiative energy release due to exciton confinement effects, unlike the planar SnS_2–x nanoflakes that show negligible heating. In vitro studies demonstrate selective cytotoxicity: SnO_x combined with NIR light (100–200 μg/mL, 30 min, 115.2 mW/cm²) reduces viability in SW837 colorectal (-50%) and A431 skin carcinoma cells (-92%), with no cytotoxicity toward human skin fibroblasts. Importantly, the SnO_x nanoflakes retain both their photothermal efficiency and structural integrity after four cycles of NIR irradiation, demonstrating stability for repeated therapeutic applications. This work presents a green and scalable method to convert NIR-inactive SnS₂ into photothermally active SnO_x nanoflakes using only aqueous media and validates SnO_x as an efficient, biocompatible PTT agent using low-cost LED sources.