スウェーデンのトップディビジョンサッカー選手における認知症リスクの高さ(Higher risk of dementia in Swedish top-division football players)

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2023-03-18 カロリンスカ研究所(KI)

新しい研究によると、20世紀中ごろまでスウェーデンのトップディビジョンでサッカーをプレーした男性は、一般人に比べて認知症のリスクが高い。ボールを頭で打つことやフィールド上でのヘッドコリジョンが認知症のリスクを増加させる可能性があるという。調査対象は6,000人以上のプロ選手で、同年代の56,000人以上の男性を対照群と比較した。調査は、1924年から2019年までの期間をカバーしており、アウトフィールドプレーヤーには高い認知症のリスクがあることが示された。
しかし、今回の研究では、パーキンソン病のリスクは32%低かった。アマチュアや若年層の選手については、研究者は今後の調査が必要と述べた。

<関連情報>

スウェーデンの男子エリートサッカー選手における神経変性疾患:コホート研究 Neurodegenerative disease among male elite football (soccer) players in Sweden: a cohort study

Peter Ueda, Björn Pasternak, Carl-Emil Lim,Prof Martin Neovius, Manzur Kader, Magnus Forssblad, Jonas F Ludvigsson, Henrik Svanström
The Lancet Public Health  Published:March 16, 2023
DOI:https://doi.org/10.1016/S2468-2667(23)00027-0

スウェーデンのトップディビジョンサッカー選手における認知症リスクの高さ(Higher risk of dementia in Swedish top-division football players)

Summary

Background
Football (soccer) players might be at increased risk of neurodegenerative disease, which has led to questions regarding the safety of the sport and recent measures introduced by football associations to reduce heading of the ball. We aimed to assess the risk of neurodegenerative disease among male football players in the Swedish top division Allsvenskan, compared with matched controls.

Methods
In this cohort study, we identified all male football players (amateurs and professionals) who had played at least one game in Allsvenskan from Aug 1, 1924 to Dec 31, 2019 and excluded players whose personal identity number could not be retrieved or be identified in the Total Population Register, and those who were not born in Sweden and who had immigrated to the country after age 15 years. Football players were matched with up to ten controls from the general population according to sex, age, and region of residence. We used nationwide registers to compare the risk of neurodegenerative disease (diagnoses recorded in death certificates, during hospital admissions and outpatient visits, or use of prescription drugs for dementia) among football players versus controls. We also assessed each type of neurodegenerative disease (Alzheimer’s disease and other dementias, motor neuron disease, and Parkinson’s disease) separately, and compared the risk of neurodegenerative disease among outfield players versus goalkeepers.

Findings
Of 7386 football players who had played at least one game in the top Swedish division between Aug 1, 1924, and Dec 31, 2019, 182 players were excluded for an unretrievable personal identity number, and 417 were excluded due to their number not being identified in the Total Population Register. After a further exclusion of 780 players and 11 627 controls who were born outside of Sweden and who had immigrated to the country after age 15 years, 6007 football players (510 goalkeepers) were included in the study population along with 56 168 matched controls. During follow-up to Dec 31, 2020, 537 (8·9%) of 6007 football players and 3485 (6·2%) of 56 168 controls were diagnosed with neurodegenerative disease. The risk of neurodegenerative disease was higher among football players than controls (hazard ratio [HR] 1·46 [95% CI 1·33–1·60]). Alzheimer’s disease and other dementias were more common among football players than controls (HR 1·62 [95% CI 1·47–1·78]), significant group differences were not observed for motor neuron disease (HR 1·27 [0·73–2·22]), and Parkinson’s disease was less common among football players (HR 0·68 [0·52–0·89]). The risk of neurodegenerative disease was higher for outfield players than controls (HR 1·50 [95% CI 1·36–1·65]) but not for goalkeepers versus controls (HR 1·07 [0·78–1·47]), and outfield players had a higher risk of neurodegenerative disease than did goalkeepers (HR 1·43 [1·03–1·99]). All-cause mortality was slightly lower among football players than controls (HR 0·95 [95% CI 0·91–0·99]).

Interpretation
In this cohort study, male football players who had played in the Swedish top division had a significantly increased risk of neurodegenerative disease compared with population controls. The risk increase was observed for Alzheimer’s disease and other dementias but not for other types of neurodegenerative disease, and among outfield players, but not among goalkeepers. Our study expands on the data that can be used to assess and manage risks in the sport.

Funding
Karolinska Institutet, The Swedish Research Council for Sport Science, Folksam Research Foundation, Hedberg Foundation, Neurofonden, and Åhlen Foundation.

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