2023-07-05 バース大学
Many drugs like paracetamol and ibuprofen are made using crude oil products, which is unsustainable. (Image by H_Ko)
◆この方法では、連続的なフローリアクターを使用して製造を行い、生産を中断することなくスケールアップが容易です。現時点では、このプロセスは石油由来の原料を使用する方法よりも費用がかかるかもしれませんが、植物由来の持続可能な医薬品に対してわずかに高い価格を支払うことに消費者は準備ができている可能性があります。
<関連情報>
- https://www.bath.ac.uk/announcements/scientists-make-common-pain-killers-from-pine-trees-instead-of-crude-oil/
- https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.202300670
バイオリニューアブルなβ-ピネンからのパラセタモールとイブプロフェンの持続可能な合成 Sustainable Syntheses of Paracetamol and Ibuprofen from Biorenewable β-pinene
Joshua Dale Tibbetts, Marc Hutchby, William B. Cunningham, Robert S. L. Chapman, Gabriele Kociok-Köhn, Matthew G. Davidson, Steven Dean Bull
ChemSusChem Published: 18 June 2023
DOI:https://doi.org/10.1002/cssc.202300670
Abstract
Scalable processes have been developed to convert β-pinene into 4-isopropenylcyclohexanone which is then used as a feedstock for the divergent synthesis of sustainable versions of the common painkillers, paracetamol and ibuprofen. Both synthetic routes use Pd(0) catalysed reactions to aromatise the cyclohexenyl rings of key intermediates to produce the benzenoid ring systems of both drugs. The potential of using bioderived 4-hydroxyacetophenone as a drop-in feedstock replacement to produce sustainable aromatic products is also discussed within a terpene biorefinery context.
