2023-09-27 ペンシルベニア州立大学(PennState)
◆このデバイスは、汗のバイオマーカー濃度の低さやpH、塩分、温度の変動に対応し、特異的なグルコース測定を提供します。ウェアラブルパッチは、個別および集団の健康、個別医療、精密栄養などに適しており、連続的なモニタリングを可能にします。
<関連情報>
- https://www.psu.edu/news/engineering/story/new-wearable-sensor-makes-continuous-analysis-sweat-possible-researchers-say/
- https://onlinelibrary.wiley.com/doi/10.1002/adfm.202306117
汗中のバイオマーカーを連続分析する高感度かつ長期安定性のウェアラブルパッチ A Highly Sensitive and Long-Term Stable Wearable Patch for Continuous Analysis of Biomarkers in Sweat
Farnaz Lorestani, Xianzhe Zhang, Abu Musa Abdullah, Xin Xin, Yushen Liu, Md Mashfiqur Rahman, Md Abu Sayeed Biswas, Bowen Li, Ankan Dutta, Zhenyuan Niu, Shuvendu Das, Shishir Barai, Ke Wang, Huanyu Cheng
Advanced Functional Materials Published: 13 September 2023
DOI:https://doi.org/10.1002/adfm.202306117
Abstract
Although increasing efforts have been devoted to the development of non-invasive wearable electrochemical sweat sensors for monitoring physiological and metabolic information, most of them still suffer from poor stability and specificity over time and fluctuating temperatures. This study reports the design and fabrication of a long-term stable and highly sensitive flexible electrochemical sensor based on nanocomposite-modified porous graphene by facile laser treatment for detecting biomarkers such as glucose in sweat. The laser-reduced and patterned stable conductive nanocomposite on the porous graphene electrode provides the resulting glucose sensor with an excellent sensitivity of 1317.69 µA mm-1 cm-2 and an ultra-low limit of detection of 0.079 µm. The sensor can also detect pH and exhibit extraordinary stability to maintain more than 91% sensitivity over 21 days in ambient conditions. Taken together with a temperature sensor based on the same material system, the dual glucose and pH sensor integrated with a flexible microfluidic sweat sampling network further results in accurate continuous on-body glucose detection calibrated by the simultaneously measured pH and temperature. The low-cost, highly sensitive, and long-term stable platform could facilitate the early identification and continuous monitoring of different biomarkers for non-invasive disease diagnosis and treatment evaluation.
