2023-09-28 カリフォルニア大学サンディエゴ校(UCSD)
◆このセンサーは、押し印のような柔軟な表面にスクリーン印刷された2つの柔軟なセンサーを追加することで実現され、データはイヤーバッドと通信し、その後、データはスマートフォンまたはラップトップで視覚化および詳細な分析のためにワイヤレスで送信される。これらのセンサーは、長期間の健康モニタリングおよび長期の神経変性疾患の検出に使用できる。
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脳活動と汗中の乳酸を継続的にモニタリングする耳内統合型センサーアレイ In-ear integrated sensor array for the continuous monitoring of brain activity and of lactate in sweat
Yuchen Xu,Ernesto De la Paz,Akshay Paul,Kuldeep Mahato,Juliane R. Sempionatto,Nicholas Tostado,Min Lee,Gopabandhu Hota,Muyang Lin,Abhinav Uppal,William Chen,Srishty Dua,Lu Yin,Brian L. Wuerstle,Stephen Deiss,Patrick Mercier,Sheng Xu,Joseph Wang & Gert Cauwenberghs
Nature Biomedical Engineering Published:28 September 2023
DOI:https://doi.org/10.1038/s41551-023-01095-1
Abstract
Owing to the proximity of the ear canal to the central nervous system, in-ear electrophysiological systems can be used to unobtrusively monitor brain states. Here, by taking advantage of the ear’s exocrine sweat glands, we describe an in-ear integrated array of electrochemical and electrophysiological sensors placed on a flexible substrate surrounding a user-generic earphone for the simultaneous monitoring of lactate concentration and brain states via electroencephalography, electrooculography and electrodermal activity. In volunteers performing an acute bout of exercise, the device detected elevated lactate levels in sweat concurrently with the modulation of brain activity across all electroencephalography frequency bands. Simultaneous and continuous unobtrusive in-ear monitoring of metabolic biomarkers and brain electrophysiology may allow for the discovery of dynamic and synergetic interactions between brain and body biomarkers in real-world settings for long-term health monitoring or for the detection or monitoring of neurodegenerative diseases.
