2023-10-13 マックス・プランク研究所
◆この研究では、27人の女性を対象に、月経周期中の6つの異なる時点で脳の構造を調査し、エストラジオールとプロゲステロンといった性ホルモンが脳の特定の領域に影響を与えることを明らかにしました。これにより、月経周期における女性の脳の変化が初めて詳細に調査され、ホルモンのリズムと脳の関連が浮かび上がりました。女性の脳の研究は未だに不足しており、性ホルモンの影響を理解するためにはさらなる研究が必要とされています。
<関連情報>
- https://www.mpg.de/20964081/1013-nepf-the-menstrual-rhythm-of-the-brain-149575-x
- https://www.nature.com/articles/s44220-023-00125-w
超高磁場7T MRIにより、女性成人における月経周期中のヒト内側側頭葉容積の変化が明らかになる Ultra-high-field 7T MRI reveals changes in human medial temporal lobe volume in female adults during menstrual cycle
Rachel G. Zsido,Angharad N. Williams,Claudia Barth,Bianca Serio,Luisa Kurth,Toralf Mildner,Robert Trampel,Frauke Beyer,A. Veronica Witte,Arno Villringer & Julia Sacher
Nature Mental Health Published:05 October 2023
DOI:https://doi.org/10.1038/s44220-023-00125-w
Abstract
Ovarian hormones have substantial effects on the brain, and early menopause has been associated with increased risk of accelerated brain aging and dementia later in life. However, the impact of ovarian hormone fluctuations on brain structure earlier in life is less understood. Here we show that ovarian hormone fluctuations shape structural brain plasticity during the reproductive years. We use longitudinal ultra-high field neuroimaging across the menstrual cycle to map the morphology of medial temporal lobe subregions in 27 participants. Controlling for water content and blood flow, our findings reveal positive associations between estradiol and parahippocampal cortex volume, progesterone and subiculum and perirhinal area 35 volumes, and an estradiol*progesterone interaction with CA1 volume. This research offers a blueprint for future studies on the shared dynamics of the brain and ovarian function and a fundamental stepping stone towards developing sex-specific strategies to improve brain health and mental health.
