研究者らは、個々のニューロンの集合を数ヶ月にわたって記録できる埋め込み型デバイスを開発した Researchers develop implantable device that can record a collection of individual neurons over months
2026-01-26 ハーバード大学
◆これにより、硬質なシリコンインプラントの持続性と柔軟な小型デバイスの高解像度情報提供のトレードオフを克服し、数ヶ月にわたって単一ニューロン活動を記録できます。この技術は、将来の脳-コンピュータインターフェースや医療機器ベースの治療法に革新をもたらす可能性があります。
<関連情報>
- https://seas.harvard.edu/news/2024/01/long-lasting-neural-probe
- https://www.nature.com/articles/s41565-023-01545-6
フッ素化エラストマーに基づく3D時空間スケーラブル生体内神経プローブ 3D spatiotemporally scalable in vivo neural probes based on fluorinated elastomers
Paul Le Floch,Siyuan Zhao,Ren Liu,Nicola Molinari,Eder Medina,Hao Shen,Zheliang Wang,Junsoo Kim,Hao Sheng,Sebastian Partarrieu,Wenbo Wang,Chanan Sessler,Guogao Zhang,Hyunsu Park,Xian Gong,Andrew Spencer,Jongha Lee,Tianyang Ye,Xin Tang,Xiao Wang,Katia Bertoldi,Nanshu Lu,Boris Kozinsky,Zhigang Suo & Jia Liu
Nature Nanotechnology Published:22 December 2023
DOI:https://doi.org/10.1038/s41565-023-01545-6
Abstract
Electronic devices for recording neural activity in the nervous system need to be scalable across large spatial and temporal scales while also providing millisecond and single-cell spatiotemporal resolution. However, existing high-resolution neural recording devices cannot achieve simultaneous scalability on both spatial and temporal levels due to a trade-off between sensor density and mechanical flexibility. Here we introduce a three-dimensional (3D) stacking implantable electronic platform, based on perfluorinated dielectric elastomers and tissue-level soft multilayer electrodes, that enables spatiotemporally scalable single-cell neural electrophysiology in the nervous system. Our elastomers exhibit stable dielectric performance for over a year in physiological solutions and are 10,000 times softer than conventional plastic dielectrics. By leveraging these unique characteristics we develop the packaging of lithographed nanometre-thick electrode arrays in a 3D configuration with a cross-sectional density of 7.6 electrodes per 100 µm2. The resulting 3D integrated multilayer soft electrode array retains tissue-level flexibility, reducing chronic immune responses in mouse neural tissues, and demonstrates the ability to reliably track electrical activity in the mouse brain or spinal cord over months without disrupting animal behaviour.
