2024-06-05 バッファロー大学(UB)
<関連情報>
- https://www.buffalo.edu/news/releases/2024/06/stem-cell-therapy-MS.html
- https://www.science.org/doi/full/10.1126/sciadv.adk9918
注入可能な剪断減粘性ハイドロゲルは中枢神経系におけるオリゴデンドロサイト前駆細胞の生存と再髄鞘化を促進する Injectable shear-thinning hydrogels promote oligodendrocyte progenitor cell survival and remyelination in the central nervous system
ASHIS KUMAR PODDER, MOHAMED ALAA MOHAMED, RICHARD A. SEIDMAN, GEORGIOS TSEROPOULOS, […], AND STELIOS T. ANDREADIS
Science Advances Published:12 Jul 2024
DOI:https://doi.org/10.1126/sciadv.adk9918
Abstract
Cell therapy for the treatment of demyelinating diseases such as multiple sclerosis is hampered by poor survival of donor oligodendrocyte cell preparations, resulting in limited therapeutic outcomes. Excessive cell death leads to the release of intracellular alloantigens, which likely exacerbate local inflammation and may predispose the graft to eventual rejection. Here, we engineered innovative cell-instructive shear-thinning hydrogels (STHs) with tunable viscoelasticity and bioactivity for minimally invasive delivery of primary human oligodendrocyte progenitor cells (hOPCs) to the brain of a shiverer/rag2 mouse, a model of congenital hypomyelinating disease. The STHs enabled immobilization of prosurvival signals, including a recombinantly designed bidomain peptide and platelet-derived growth factor. Notably, STHs reduced the death rate of hOPCs significantly, promoted the production of myelinating oligodendrocytes, and enhanced myelination of the mouse brain 12 weeks post-implantation. Our results demonstrate the potential of STHs loaded with biological cues to improve cell therapies for the treatment of devastating myelopathies.
