2024-11-12 カナダ・ブリティッシュコロンビア大学(UBC)
<関連情報>
- https://news.ubc.ca/2024/11/blood-vessel-like-coating-could-make-medical-devices-safer-for-patients/
- https://www.nature.com/articles/s41563-024-02046-0
正電荷を保護した抗血栓性コーティングは、第XII因子-生体界面結合を制御することにより接触活性化を防ぐ Antithrombotic coating with sheltered positive charges prevents contact activation by controlling factor XII–biointerface binding
Haifeng Ji,Kai Yu,Srinivas Abbina,Lin Xu,Tao Xu,Shengjun Cheng,Sreeparna Vappala,S. M. Amin Arefi,Md Mohosin Rana,Irina Chafeeva,Matthew Drayton,Kevin Gonzalez,Yun Liu,Dana Grecov,Edward M. Conway,Weifeng Zhao,Changsheng Zhao & Jayachandran N. Kizhakkedathu
Nature Materials Published:12 November 2024
DOI:https://doi.org/10.1038/s41563-024-02046-0
Abstract
Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices. Such materials would restrain device-induced thrombogenesis and decrease the need for anticoagulant use, thereby reducing unwanted bleeding. Here, by optimizing the interactions with coagulation factor XII rather than preventing its surface adsorption, we develop a substrate-independent antithrombotic polymeric coating with sheltered positive charges. The antithrombic properties of the coating were demonstrated in vitro with human blood and in vivo using a carotid artery–jugular vein shunt model in rabbits. The coating exhibits a strong interaction with factor XII, but results in a low reciprocal activation of the contact pathway that triggers clot formation. These findings contradict the prevailing strategy of designing antithrombotic materials through protein-repelling surfaces. Overall, the polymeric coating we describe can benefit most blood-contacting devices and is a useful engineering guideline for designing surfaces with improved antithrombotic properties.
