2024-12-23 ペンシルベニア州立大学(PennState)
Salmonella infections in dogs may be an overlooked transmission vector to humans, researchers reported in a new study. Credit: SeventyFour/Getty Images. All Rights Reserved.
<関連情報>
- https://www.psu.edu/news/research/story/pet-dogs-often-overlooked-spreader-antimicrobial-resistant-salmonella
- https://onlinelibrary.wiley.com/doi/10.1111/zph.13174
家庭犬由来非チフス性サルモネラの抗菌薬耐性と人獣共通感染症の可能性 Antimicrobial Resistance and Zoonotic Potential of Nontyphoidal Salmonella From Household Dogs
Sophia M. Kenney, Nkuchia M. M’ikanatha, Erika Ganda
Zoonoses and Public Health Published: 15 November 2024
DOI:https://doi.org/10.1111/zph.13174
ABSTRACT
Background
Companion animals, like household dogs, are an overlooked transmission point for zoonotic pathogens such as nontyphoidal Salmonella (NTS). Given the proximity of dogs to humans and the use of critically important antibiotics in companion animal medicine, household dogs represent a risk for the spread of antimicrobial-resistant (AMR) Salmonella.
Methods and Results
To this end, we aimed to leverage existing biosurveillance infrastructure to investigate AMR and the zoonotic potential of NTS isolated from dogs and humans. We identified all NTS strains isolated from domestic dogs via the Veterinary Laboratory Investigation and Response Network between May 2017 and March 2023 (N = 87), and spatiotemporally matched strains isolated from humans in the NCBI Pathogen Isolate Browser (N = 77). These 164 strains, collected from 17 states in the United States, formed the basis of our analysis. Strains isolated from dogs comprised diverse serovars, with most being clinically relevant to human health. All strains possessed AMR determinants for drug classes deemed critically or highly important by the World Health Organization. We identified sixteen NTS isolates from humans closely related to ≥1 of six dog-associated strains.
Conclusions
Collectively, our data emphasize the importance of antimicrobial stewardship and sustained biosurveillance beyond human- and agriculture-associated veterinary medicine, using a One-Health framework that accounts for all transmission points including companion animals.
