2025-02-24 ラトガース大学
<関連情報>
- https://www.rutgers.edu/news/new-study-raises-alarm-over-alzheimers-blood-tests
- https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14585
2つの多様なコホートにおける認知障害と人種が血漿p-Tau217に及ぼす影響 Influence of cognitive impairment and race on plasma p-Tau217 in two diverse cohorts
Ashima Nayyar, Mei-ling Li, Victor Sotelo, Guibin Su, Isabelle Hwang, Milota Kaluzova, Mini Jomartin, Michelle Migut, Hilary Grosso Jasutkar, Karlyndsay Sitterley, Karthik J. Kota, William T. Hu
Alzheimer’s & Dementia Published: 23 February 2025
DOI:https://doi.org/10.1002/alz.14585
Abstract
INTRODUCTION
Factors influencing plasma Alzheimer’s disease (AD) biomarkers remain incompletely understood. Here we evaluated Fujirebio plasma p-Tau217 in two diverse cohorts among whom 91% underwent cerebrospinal fluid (CSF) analysis.
METHODS
Non-Hispanic White (NHW, n = 113), Black/African American (B/AA, n = 66), and Chinese American (ChA, n = 38) participants recruited from two universities were included. We examined if plasma p-Tau217 correlated with CSF and clinical factors, differed between racial groups, and associated with novel CSF proteins.
RESULTS
CSF p-Tau181 strongly correlated with CSF p-Tau217 (R2 = 0.912) which moderately correlated with plasma p-Tau217 (R2 = 0.694). Plasma p-Tau217 levels were higher with greater cognitive impairment but lower in B/AA than NHW participants even after adjusting for CSF p-Tau181. This resulted in greater positive predictive value for NHW than B/AA participants, and could be mediated by complement or lysosomal pathways.
DISCUSSION
Severity of cognitive impairment and race both influence plasma p-Tau217 levels beyond race-associated differences in CSF p-Tau181.
Highlights
- Cognitive impairment associates with plasma p-Tau217 independent of CSF biomarkers.
- Black/African Americans had lower plasma p-Tau217 than non-Hispanic White Americans.
- CSF p-Tau181 could not explain lower plasma p-Tau217 in Black/African Americans.
- Plasma p-Tau217 difference results in more false positive cases according to race.
- Novel CSF processes were associated with race-related plasma p-Tau217 difference.
