2025-03-11 アイルランド・リムリック大学(UL)
<関連情報>
- https://www.ul.ie/news/new-university-of-limerick-research-identifies-groups-at-high-risk-of-chronic-kidney-disease
- https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfaf065/8058883
アイルランドの50歳以上の地域居住成人における慢性腎臓病の有病率と決定要因 Prevalence and determinants of chronic kidney disease among community-dwelling adults, 50 years and older in Ireland
Meera Tandan, Leonard D Browne, Amir Jalali, Colm Rowan, Frank Moriarty, Austin G Stack
Clinical Kidney Journal Published:11 March 2025
DOI:https://doi.org/10.1093/ckj/sfaf065
Graphical Abstract
Abstract
Background
Using the Irish Longitudinal Study on Ageing (TILDA), we evaluated the prevalence and distribution of chronic kidney disease (CKD), and its determinants in order to identify risk groups for population health planning in Ireland.
Methods
Data were analysed from Wave 1 (2009-2011) of the TILDA, a national cohort of participants aged 50+ who had both plasma creatinine and cystatin C measured at baseline. Kidney function was estimated using the 2012 and 2021 CKD-EPI equations. CKD was defined as eGFR < 60 ml/min/1.73 m². Multivariable logistic regression explored associations using adjusted odds ratios (OR).
Results
Prevalence of CKD was significantly higher using the CKD-EPI 2012(Scr-CysC) compared to the CKD-EPI 2021(Scr-CysC) (14.7% versus 11.3% respectively). The prevalence was highest in patients with cardiovascular disease [CVD] (33.9%), diabetes (28.0%), cancer (25.5%), urinary incontinence (23.7%), bone diseases (21.5%), hypertension (19.8%), and obesity (19.5%). In multivariable analysis, individuals with hypertension (OR 1.78), diabetes (OR 1.45), CVD (OR 1.43), cancer (OR 1.53), overweight (OR 1.37) and obesity (OR 2.33) experienced greater likelihood of CKD. In addition, individuals with a history of previous hospitalization (OR 1.50), free or subsidized healthcare (OR 1.31), and unemployed individuals (OR 1.86) were also significantly more likely to have CKD.
Conclusion
Compared to the national average, the burden of CKD is far greater in older individuals with major chronic conditions and socioeconomic deprivation. The identification and targeting of these groups through national surveillance programmes is likely to yield substantial benefits from more effective disease management and proactive population health planning.
