2025-03-13 マックス・プランク研究所 (MPG)
<関連情報>
- https://www.mpg.de/24290329/predatory-behaviour-is-an-inherited-trait-across-multiple-generations-in-nematodes
- https://www.science.org/doi/10.1126/sciadv.adu0875
EBAX-1/ZSWIM8はmiRNAを不安定化し、捕食形質を世代を超えて遺伝させる EBAX-1/ZSWIM8 destabilizes miRNAs, resulting in transgenerational inheritance of a predatory trait
Shiela Pearl Quiobe, Ata Kalirad, Waltraud Röseler, Hanh Witte, […], and Ralf J. Sommer
Science Advances Published:12 Mar 2025
DOI:https://doi.org/10.1126/sciadv.adu0875
Abstract
Environmental influences on traits and associated transgenerational epigenetic inheritance have widespread implications but remain controversial and underlying mechanisms poorly understood. We introduce long-term environmental induction experiments on alternative diets in Pristionchus pacificus, a nematode exhibiting mouth-form plasticity including predation, by propagating 110 isogenic lines for 101 generations with associated food-reversal experiments. We found dietary induction and subsequent transgenerational inheritance of the predatory morph and identified a role of ubiquitin ligase EBAX-1/ZSWIM8 in this process. Ppa-ebax-1 mutants are transgenerational inheritance defective, and Ppa-EBAX-1 destabilizes the clustered microRNA family miR-2235a/miR-35. Deletions of a cluster of 44 identical miR-2235a copies resulted in precocious and extended transgenerational inheritance of the predatory morph. These findings indicate that EBAX-1/ZSWIM8 destabilizes miRNAs, resulting in transgenerational inheritance, suggesting a role for target-directed miRNA degradation.
