2025-04-02 東京科学大学
図1. COVID-19パンデミックにおける高齢者のヘルペスウイルス再活性化とぶどう膜炎の発症
<関連情報>
- https://www.isct.ac.jp/ja/news/vxzar112fzkl
- https://www.isct.ac.jp/plugins/cms/component_download_file.php?type=2&pageId=&contentsId=1&contentsDataId=1223&prevId=&key=c3ab13344f6591844a1cf01c1393ebea.pdf
- https://onlinelibrary.wiley.com/doi/10.1002/jmv.70286
静かなる伝染病: 高齢者のヘルペス性ぶどう膜炎を解明する The Silent Epidemic: Unveiling Herpetic Uveitis in the Elderly
Yuan Zong, Koju Kamoi, Jing Zhang, Mingming Yang, Yaru Zou, Miki Miyagaki, Kyoko Ohno-Matsui
Journal of Medical Virology Published: 07 March 2025
DOI:https://doi.org/10.1002/jmv.70286
ABSTRACT
In aging societies, uveitis—a leading cause of vision loss due to ocular inflammation—is increasingly prevalent, especially among older people. This study aimed to determine the trends and contributing factors of herpetic uveitis in older people, reflecting the broader impact of demographic shifts on ocular health. A retrospective study at the Institute of Science Tokyo reviewed uveitis cases in patients aged ≥ 65 years between 2012 and 2022. Among the 1095 older patients diagnosed with uveitis, 65 (5.9%) had herpesvirus uveitis, predominantly manifesting as unilateral anterior uveitis, with cytomegalovirus as the most common virus. Male predominance in herpetic uveitis cases was identified. The study also noted a significantly higher incidence of unilateral onset in herpetic cases compared to non-herpetic ones (p < 0.05). There was a trend toward a higher rate of secondary glaucoma in herpetic cases. Post-2020, an upsurge in herpetic uveitis diagnoses was recorded, potentially linked to the immunosuppressive effects of the coronavirus disease 2019 pandemic. Additionally, rare and severe acute retinal necrosis was identified in the study cohort. These findings highlight the growing trend of herpetic uveitis in older people in Japan and emphasize the necessity for advanced monitoring, diagnostic accuracy, and treatment strategies for herpes uveitis in aging populations globally.
