2025-04-02 ジョンズ・ホプキンス大学
<関連情報>
- https://hub.jhu.edu/2025/04/02/how-alcohol-abuse-damages-cognition/
- https://www.science.org/doi/10.1126/sciadv.adt0200
慢性的なエタノール曝露は線条体における価値計算において性差に依存した障害をもたらす Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum
Yifeng Cheng, Robin Magnard, Angela J. Langdon, Daeyeol Lee, and Patricia H. Janak
Science Advances Published:2 Apr 2025
DOI:https://doi.org/10.1126/sciadv.adt0200
Abstract
Value-based decision-making relies on the striatum, where neural plasticity can be altered by chronic ethanol (EtOH) exposure, but the effects of such plasticity on striatal neural dynamics during decision-making remain unclear. This study investigated the long-term impacts of EtOH on reward-driven decision-making and striatal neurocomputations in male and female rats using a dynamic probabilistic reversal learning task. Following a prolonged withdrawal period, EtOH-exposed male rats exhibited deficits in adaptability and exploratory behavior, with aberrant outcome-driven value updating that heightened preference for chosen action. These behavioral changes were linked to altered neural activity in the dorsomedial striatum (DMS), where EtOH increased outcome-related encoding and decreased choice-related encoding. In contrast, female rats showed minimal behavioral changes with distinct EtOH-evoked alterations of neural activity, revealing significant sex differences in the impact of chronic EtOH. Our findings underscore the impact of chronic EtOH exposure on adaptive decision-making, revealing enduring changes in neurocomputational processes in the striatum underlying cognitive deficits that differ by sex.
