無煙たばこの中止が体重と血圧の上昇を引き起こす(Snus cessation led to increased body weight and blood pressure)

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2025-05-15 リンショーピング大学

スウェーデンのリンショーピング大学の研究チームは、スヌース(無煙たばこ)を12週間中止した33人を対象にした研究で、平均3.7mmHgの収縮期血圧の上昇と1.8kgの体重増加を確認しました。この結果は、ニコチン摂取の中止が血圧低下をもたらすという従来の予想に反し、血圧が上昇したことが示されました。研究対象者は18~70歳で、65%が男性、使用していたスヌースの種類はタバコスヌース(65%)とニコチンスヌース(32%)でした。研究期間中、参加者は毎日自宅で血圧を測定し、血糖値や脂質、インスリンなどの代謝指標も定期的に評価されました。研究を主導したフレドリック・ニーストロム教授は、スヌースの中止が心血管系に予期せぬ影響を及ぼす可能性があると指摘し、特に高血圧や心血管疾患のリスクがある人々は、禁煙後も血圧や体重のモニタリングが重要であると述べています。この研究成果は、Harm Reduction Journalに掲載されました。

<関連情報>

12週間のタバコとニコチンパウチの禁煙による心血管と代謝の変化:スウェーデンのコホート研究 Cardiovascular and metabolic changes following 12 weeks of tobacco and nicotine pouch cessation: a Swedish cohort study

Peder af Geijerstam,Annelie Joelsson,Karin Rådholm & Fredrik H. Nyström
Harm Reduction Journal  Published:16 April 2025
DOI:https://doi.org/10.1186/s12954-025-01195-y

無煙たばこの中止が体重と血圧の上昇を引き起こす(Snus cessation led to increased body weight and blood pressure)

Abstract

Objectives

Use of snus, including tobacco and nicotine pouches, is increasing in many countries. Nicotine increases blood pressure (BP) acutely, but the long-term effects of quitting the regular use of snus pouches are unknown. The aim was to evaluate the effects of snus cessation on home BP and markers of the metabolic syndrome.

Methods

Volunteers aged 18–70 years using snus daily were invited to abruptly end their snus intake and followed using home BP and metabolic measurements before and for 12 weeks after cessation.

Results

Fifty volunteers were recruited. Of these, 46 (92%) attempted snus cessation and 37 (74%) did not use snus for at least 3 weeks and were included in the study. Of those included, 33 maintained snus cessation for all 12 weeks. The mean age was 38 (± 10) years and 24 (65%) were men. At week 12, the mean changes in systolic home BP was 3.7 (95% CI 1.5–5.9) mmHg, in body weight was 1.8 (95% CI 1.1–2.4) kg, and in HbA1c was 0.7 (95% CI 0.0–1.6) mmol/mol.

Conclusions

Cessation of tobacco and nicotine pouches in individuals who regularly used snus negatively impacted systolic home BP, body weight and HbA1c after 12 weeks. Whether these effects would be reversed by snus re-initiation cannot be determined by this study, but our novel findings suggest that successful cessation of regular snus usage does not immediate improve these cardiovascular risk factors. We call for further research to confirm our findings and evaluate the effects over longer time frames.

Clinical Trial Registry number

NCT06019910, https://clinicaltrials.gov/study/NCT06019910.

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