2025-05-20 中国科学院(CAS)
Novel skeletal structures of Corymbinols A and B isolated from C. citriodora fruits.(Imaged by QIU et al)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202505/t20250522_1044250.shtml
- https://pubs.acs.org/doi/10.1021/acs.orglett.5c01245
コリンビノールAおよびB:Corymbia citriodoraの果実から得られるセスキテルペンとカルコンのビス-β-トリケトン共役体 Corymbinols A and B: Bis-β-triketone Conjugates of Sesquiterpene and Chalcone from the Fruit of Corymbia citriodora
Yu-Lin Li,Xiao Ding,Xian-Le Duan,Aikebaier Jumai,Yu-Cheng Gu,Li-Yun Zhao,Xuan Ma,Xiao-Jiang Hao,and Sheng-Xiang Qiu
Organic Letters Published: May 9, 2025
DOI:https://doi.org/10.1021/acs.orglett.5c01245
Abstract
Corymbinols A (1) and B (2a/2b), unprecedented bis-β-triketone-sesquiterpene and -chalcone hybrids, together with their biogenic precursors corymbinol C (3) and rhodomyrtosone E (4) were isolated from the untapped fruit of Corymbia citriodora. The absolute configurations of these compounds were determined by NMR spectroscopy, electronic circular dichroism (ECD) calculations, and X-ray crystallography. Compound 1 exhibited moderate inhibitory activity against cuproptosis in HepG2 cells by 31% at a nontoxic concentration of 20 μM.
