2025-10-31 カリフォルニア大学ロサンゼルス校(UCLA)
<関連情報>
- https://newsroom.ucla.edu/releases/alarming-rise-in-severe-diverticulitis-younger-americans
- https://journals.lww.com/dcrjournal/abstract/2025/05000/national_trends_in_hospital_admissions,.13.aspx
2005年から2020年までの早期発症(50歳未満)憩室炎の入院、介入、および転帰に関する全国的傾向 National Trends in Hospital Admissions, Interventions, and Outcomes for Early-Onset (Age <50 years) Diverticulitis From 2005 to 2020
Kim, Shineui B.A.; Kwon, Oh Jin M.D.; Chervu, Nikhil L. M.S., M.D.; Mallick, Saad M.D.; Ali, Konmal B.S.; Benharash, Peyman M.D.; Hawkins, Alexander T. M.D., M.P.H.; Lee, Hanjoo M.D.; Khan, Aimal M.D.
Diseases of the Colon & Rectum Published:May 2025
DOI:10.1097/DCR.0000000000003668
Abstract
BACKGROUND:
Little is known about the burden and outcomes of diverticulitis in patients younger than 50 years. This knowledge gap hinders the development of effective management strategies and preventive measures for this population.
OBJECTIVE:
This study aimed to analyze national trends in hospitalizations, interventions, and outcomes for early-onset diverticulitis (age younger than 50 years) in comparison to standard-onset diverticulitis (age 50 years or older) cohorts.
DESIGN:
Retrospective cohort study.
SETTINGS:
A survey-weighted, national sample extracted from the National Inpatient Sample.
PATIENTS:
All adults (18 years or older) hospitalized for diverticulitis between 2005 and 2020 were included.
MAIN OUTCOME MEASURES:
National trends in the proportions of early-onset versus standard-onset diverticulitis were found to be related, along with the rates of colectomy.
RESULTS:
From 2005 to 2020, 5,239,735 patients were nonelectively hospitalized for diverticulitis. Of them, 837,195 (16.0%) were early onset. During the study period, the proportion of the early-onset cohort admitted for complicated diverticulitis significantly increased from 18.5% to 28.2% (nonparametric trend < 0.001). In addition, there was a decline in the proportion of early-onset diverticulitis patients needing a colectomy (34.7%–20.3%, nonparametric trend < 0.001), with a corresponding increase in the proportion of patients needing interventional radiology intervention (12.7%–28.6%, nonparametric trend < 0.001). Compared to standard-onset diverticulitis, early-onset diverticulitis was associated with decreased odds of mortality (adjusted OR 0.18; 95% CI, 0.16–0.20; p < 0.001) as well as decreased length of stay (β –0.28 days; 95% CI, –0.32 to –0.24; p < 0.001) and hospitalization costs (β –$1900; 95% CI, –$2100 to –$1800; p < 0.001). In addition, early-onset diverticulitis was associated with increased odds of colectomy (adjusted OR 1.29; 95% CI, 1.26–1.31) and percutaneous drainage (adjusted OR 1.58; 95% CI, 1.53–1.62).
LIMITATIONS:
Retrospective data collection. Lack of granular clinical data.
CONCLUSIONS:
There has been a significant increase in the proportion of complicated diverticulitis-related admissions among patients younger than 50 years. Patients with early-onset diverticulitis were more likely to undergo colectomy or percutaneous drainage than those with standard-onset (at age 50 years or older) diverticulitis. Additional research is needed to determine the cause of these trends and identify public health policies aimed at potentially preventing the increasing burden of diverticulitis among younger populations. See Video Abstract.
