2025-11-19 マックス・プランク研究所(MPG)
Laser confocal microscope image of a ‘sleeping’ tumour cell (green) in the vicinity of a blood vessel (red/blue).
© mpihlr
<関連情報>
- https://www.mpg.de/25753427/protein-in-blood-vessels-puts-tumour-cells-into-deep-sleep
- https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-025-02488-3
肺内皮細胞PEAR1は腫瘍細胞の休眠を誘導する Lung endothelial PEAR1 induces tumor cell dormancy
Kenneth Anthony Roquid,Adriana Vucetic,Elena Dyukova,Mika J. Hanssen,Haaglim Cho,Rémy Bonnavion,Kenny Mattonet,Mario Looso,Miloslav Sanda,Boris Strilic & Stefan Offermanns
Molecular Cancer Published:03 November 2025
DOI:https://doi.org/10.1186/s12943-025-02488-3
Summary
In many cancer patients, distant metastases develop after years of dormancy. Understanding how disseminated tumor cells (DTCs), which are often found in proximity to the microvasculature, remain dormant and what regulates their reactivation is one of the major challenges in tumor biology. In a screen for endothelial secreted and plasma membrane proteins able to regulate tumor cell dormancy, we identified the transmembrane protein platelet and endothelial aggregation receptor 1 (PEAR1). Human and murine endothelial cells lacking PEAR1 lost the ability to promote dormancy of different tumor cells, and the extracellular part of PEAR1 was able to rescue this effect. Similarly, in mice lacking PEAR1 in endothelial cells, tumor cell dormancy in the lung was reduced and tumor metastasis was increased. We found that PEAR1 induces tumor cell dormancy by binding lysyl oxidase like 2 (LOXL2) and cathepsin D (CTSD), which both inhibit tumor cell dormancy and promote tumor growth and metastasis. Tumor cells with suppressed CTSD expression showed increased dormancy and decreased metastatic potential in vivo. Our data identify a mechanism underlying tumor cell dormancy and suggest CTSD and LOXL2 as targets for approaches to promote dormancy.
