2025-11-21 カリフォルニア大学リバーサイド校(UCR)
<関連情報>
- https://news.ucr.edu/articles/2025/11/21/fast-lasting-defense-against-deadly-virus
- https://www.nature.com/articles/s41541-025-01293-9
クリミア・コンゴ出血熱ウイルスレプリコン粒子ワクチンによってマウスに誘導される持続的な体液性免疫と長期防御 Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in mice
Teresa E. Sorvillo,Elif Karaaslan,Katherine A. Davies,Stephen R. Welch,Florine E. M. Scholte,JoAnn D. Coleman-McCray,Virginia Aida-Ficken,Scott D. Pegan,Éric Bergeron,Joel M. Montgomery,Christina F. Spiropoulou & Jessica R. Spengler
npj Vaccines Published:21 November 2025
DOI:https://doi.org/10.1038/s41541-025-01293-9
Abstract
A Crimean-Congo hemorrhagic fever virus replicon particle vaccine was evaluated for long-term immunity and efficacy in mice. IgG responses persisted up to 18 months, with similar titers across dosing strategies through 12 months. Protective efficacy reached ≥75% at 6 months (prime-only) and up to 12 months (prime-boost). Booster dosing enhanced antibody avidity, effector function, and improved long-term protection. These findings support durable immunity from single or boosted vaccination.
