2026-01-08 マサチューセッツ大学アマースト校
<関連情報>
- https://www.umass.edu/news/article/fight-cancer-scientists-customize-cellular-protein
- https://pubs.acs.org/doi/10.1021/jacs.5c17697
- https://pubs.acs.org/doi/10.1021/acsnano.5c02888
人工細胞由来小胞(ACDV)を介した細胞表面への機能性タンパク質の組み込みによる細胞膜リプログラミング Incorporation of Functional Proteins on Cellular Surfaces via Artificial Cell-Derived Vesicles (ACDVs) for Plasma Membrane Reprogramming
Shuai Gong,Jingyi Qiu,Fangying Huang,Jithu Krishna,Yasin Alp,Eric Strieter,and S. Thayumanavan
Journal of the American Chemical Society Published: January 15, 2026
DOI:https://doi.org/10.1021/jacs.5c17697
Abstract
The complexity of cell surface proteins and their undruggable nature remain major challenges for functional modulation strategies such as small-molecule inhibition. Here, we present an artificial cell-derived vesicle (ACDV) approach that enables the direct delivery of functional proteins onto the cell surface, bypassing the need for genetic manipulation. This programmable system converts live cells into dynamic biointerfaces capable of introducing catalytic and signaling regulation, providing a broadly applicable strategy for therapeutic cell surface engineering. These ACDVs thus represent a proof-of-concept platform for the delivery of functional biologics onto plasma membranes.
膜融合により細胞膜被覆ナノキャリアの容易な取り込みを促進 Membrane Fusion Drives Facile Uptake of Cell Membrane-Coated Nanocarriers
Jingyi Qiu,Shuai Gong,Yasin Alp,Jewel Medeiros,Emily Agnello,and S. Thayumanavan
ACS Nano Published: June 16, 2025
DOI:https://doi.org/10.1021/acsnano.5c02888
Abstract
Endocytosis has been the bane of the intracellular delivery efficiency of nanoscale systems. A class of delivery systems, viz., cell membrane-coated nanoparticles (CMNPs), show efficacious and even cell-selective uptake. We were interested in investigating the mechanism of interaction between cells and CMNPs, especially in the context of endocytic uptake and endosomal escape. We find that CMNPs are mainly taken up through a membrane-fusion-driven uptake pathway, bypassing endosomal entrapment and directly delivering therapeutic cargo to the cytoplasm. This fusion mechanism results in a significant enhancement in the intracellular delivery efficiency of both hydrophobic small molecules and nucleic acids as the cargo. The cargo-agnostic increase in delivery efficacy suggests a broad impact of this delivery system in diverse therapeutic areas.
