2026-01-30 ブラウン大学
<関連情報>
- https://www.brown.edu/news/2026-01-30/lead-exposure-childhood-depression
- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2844422
血中鉛濃度と小児のうつ病および不安症状 Blood Lead Concentrations and Depressive and Anxiety Symptoms in Childhood
Christian Hoover, MPH; George Papandonatos, PhD; Kim M. Cecil, PhD;et al
JAMA Network Open Published:January 28, 2026
DOI:10.1001/jamanetworkopen.2025.56019
Key Points
Question Is higher lead exposure during specific periods of childhood associated with increased depressive or anxiety symptoms in later childhood?
Findings In this cohort study of 218 caregiver-child dyads, increased childhood blood lead concentrations were associated with increased depressive symptoms in adolescence, with particularly large increases in depressive symptoms when exposure occurred later in childhood. No associations were observed with anxiety symptoms.
Meaning In this study, cumulative and later-childhood lead exposure was associated with increased risk of child depressive symptoms, emphasizing the need for continued efforts to reduce lead exposure throughout childhood.
Abstract
Importance Low-level lead exposure during early brain development is associated with lower cognitive abilities and externalizing behavioral problems in children. However, the association of lead exposure with depression and anxiety remains understudied, particularly in later childhood, when these symptoms often manifest.
Objective To examine associations between low-level, serial blood lead concentrations in children and symptoms of depression and anxiety and to investigate for periods of susceptibility.
Design, Setting, and Participants This cohort study used data from a prospective population of 218 caregiver-child dyads (218 children and 218 parents in the Health Outcomes and Measures of Environment [HOME] Study) recruited from 2003 to 2006 in Cincinnati, Ohio. Children and their families were followed up from the second trimester to age 12 years (2016-2019). Data were analyzed between June 2024 to November 2025.
Exposure Serial blood lead concentrations in children were measured at ages 1, 2, 3, 4, 5, 8, and 12 years.
Main Outcomes and Measures We measured self- and caregiver-reported child depressive and anxiety symptoms at age 12 years using the Behavioral Assessment System for Children–3 (BASC-3), Children’s Depression Inventory–II (CDI-II), and Screen for Child Anxiety Related Disorders (SCARED).
Results Among 218 children (121 female [55.5%]; 78 Black [35.8%] and 140 White and other race or ethnicity [64.2%]; mean [SD] age, 12.4 [0.7] years), the median (IQR; range) mean within-child blood lead concentration was 9.6 (7.8 to 12.6; 4.8 to 32.4) μg/L. Each doubling in mean childhood blood lead concentrations was associated with increased risk of elevated child-reported depressive symptoms on the BASC-3 (relative risk [RR], 1.90; 95% CI, 1.00 to 3.66; P = .05) and increased risk of child- and caregiver-reported child depressive symptoms (RR, 1.76; 95% CI, 1.12 to 2.78; P = .02). By blood lead concentration, there were increasing adjusted mean differences in self-reported BASC-3 depression scores from age 1 year (1.82; 95% CI, -1.10 to 4.74; P = .22), a nonsignificant outcome, through age 8 years (3.22; 95% CI, 0.53 to 5.90; P = .02), a significant outcome. There were no associations between blood lead concentrations and self-reported depression measured with the Children’s Depression Inventory-II or anxiety measured with the SCARED. Child sex and race did not modify these associations.
Conclusions and Relevance In this study, low-level childhood blood lead concentrations were associated with self-reported depressive symptoms in later childhood, with particularly large increases in risk for exposures occurring in late childhood and early adolescence. These findings suggest that lead exposure during childhood may be associated with mental health in later childhood, highlighting the need for continued efforts to prevent lead exposure.
