2025-03-17 カリフォルニア大学アーバイン校(UCI)
<関連情報>
- https://news.uci.edu/2025/03/17/uc-irvine-research-reveals-how-childhood-adversity-shapes-the-brain-and-behavior/
- https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900134-5
幼少期のストレスが進化する神経生物学 The evolving neurobiology of early-life stress
Matthew T. Birnie∙ Tallie Z. Baram
Neuron Published:March 17, 2025
DOI:https://doi.org/10.1016/j.neuron.2025.02.016
Summary
Because early-life stress is common and constitutes a strong risk factor for cognitive and mental health disorders, it has been the focus of a multitude of studies in humans and experimental models. Yet, we have an incomplete understanding of what is perceived as stressful by the developing brain, what aspects of stress influence brain maturation, what developmental ages are particularly vulnerable to stress, which molecules mediate the effects of stress on brain operations, and how transient stressful experiences can lead to enduring emotional and cognitive dysfunctions. Here, we discuss these themes, highlight the challenges and progress in resolving them, and propose new concepts and avenues for future research.
