2025-04-24 中国科学院(CAS)
<関連情報>
- https://english.cas.cn/newsroom/research_news/infotech/202504/t20250424_1041946.shtml
- https://www.science.org/doi/10.1126/sciadv.adu8915
高純度エクソソームの迅速単離のための振動マイクロバブルアレイベースのメタマテリアル(OMAMs) Oscillating microbubble array–based metamaterials (OMAMs) for rapid isolation of high-purity exosomes
Xinjia Li, Zhiting Deng, Wenjun Zhang, Wei Zhou, […] , and Hairong Zheng
Science Advances Published:16 Apr 2025
DOI:https://doi.org/10.1126/sciadv.adu8915
Abstract
Exosomes secreted by cells hold substantial potential for disease diagnosis and treatment. However, the rapid isolation of high-purity exosomes and their subpopulations from biofluids (e.g., undiluted whole blood) remains challenging. This study presents oscillating microbubble array–based metamaterials (OMAMs) for enabling the rapid isolation of high-purity exosomes and their subpopulations from biofluids without labeling or preprocessing. Particularly, leveraging acoustically excited microbubble oscillation, OMAMs can generate numerous acoustofluidic traps for filtering in-fluid micro/nanoparticles, thus allowing for removing bioparticles larger than exosomes to obtain high-purity (93%) exosomes from undiluted whole blood in ~3 minutes. Moreover, exosome subpopulations in different size ranges can be isolated by tuning the microbubble oscillation amplitude. Additionally, as each oscillating microbubble functions as an ultradeep subwavelength (~λ/186) acoustic amplifier and a nonlinear source, OMAMs can generate high-resolution complex acoustic energy patterns and tune the patterns by activating different-sized microbubbles at their distinct resonance frequencies.
