2025-08-15 デューク大学(Duke)
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A close-up of a nanostar created by Canning, which uses a hollow gold shell to stabilize the arms of the ‘star’
<関連情報>
- https://pratt.duke.edu/news/light-and-sound-based-thermometer-helps-gold-nanoparticles-destroy-cancer/
- https://www.science.org/doi/10.1126/sciadv.adx6350
装甲金ナノスターとリアルタイム光音響熱測定・画像化を統合することで、精密光熱療法の進展を実現 Advancing precision photothermal therapy by integrating armored gold nanostars with real-time photoacoustic thermometry and imaging
Aidan J. Canning, Tri Vu, Luca Menozzi, Paul Klippel, […] , and Tuan Vo-Dinh
Science Advances Published:13 Aug 2025
DOI:https://doi.org/10.1126/sciadv.adx6350
Abstract
Nanoparticle-mediated photothermal therapy (PTT) is a promising strategy for cancer treatment; however, nanoparticle instability and lack of precise imaging tools for real-time temperature monitoring during therapy and nanoparticle tracking have hindered investigations in animal models. To address these critical issues, we present a theranostic platform that seamlessly integrates armored core–gold nanostar (AC-GNS)–mediated PTT with full-view photoacoustic computed tomography (PACT), enabling nanoparticle tracking and real-time imaging-guided PTT in deep tissues. The AC-GNS platform delivered exceptional photostability and thermal resilience beyond those of conventional nanoparticles while serving as a high-performance contrast agent for PACT and a photothermal transducer for PTT. Integrating AC-GNS–mediated PTT with noninvasive PACT enabled whole-body nanoparticle tracking, PTT treatment monitoring via thermal imaging, and thermal dose determination, culminating in a 100% survival rate in a murine bladder cancer model without long-term treatment-related toxicity. This theranostic platform lays the foundation for broader research applications and provides opportunities for advancing solid tumor treatment and response assessment research.
