2025-09-08 京都大学iPS細胞研究所
概要図
(Biorender.comを利用して作成)
<関連情報>
- https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/250908-180000.html
- https://www.nature.com/articles/s41598-025-16446-y
MDM4は合成RNAを用いた末梢血単核球からのヒトiPS細胞効率的生成を可能とする MDM4 enables efficient human iPS cell generation from PBMCs using synthetic RNAs
Masato Nakagawa,Mizuho Nogi,Hatsuki Doi,Ryuhei Hayashi,Tomohiko Katayama,Hirohisa Ohno,Megumi Mochizuki,Karin Hayashi & Hirohide Saito
Scientific Reports Published:08 September 2025
DOI:https://doi.org/10.1038/s41598-025-16446-y
Abstract
If iPS cells can be established easily and efficiently using freshly collected blood cells, it will enhance regenerative and personalized medicine. While reports of iPS derivation from blood-derived endothelial progenitor cells using RNA have been documented, none have been reported from peripheral blood-derived mononuclear cells (PBMCs). In this study, we established a method to generate iPS cells from PBMCs using synthetic RNAs and found that MDM4, which suppresses p53, improved reprogramming efficiency.
