2025-09-09 順天堂大学
図1. 順天堂データにおける年齢とmLOYの相関関係
順天堂医院で登録された348名の前立腺がん患者のmLOYを測定。既知の報告通り、加齢とともにY染色体の割合は低下していることを確認した。
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がん患者の局所放射線治療は、男性の老化の特徴であるY染色体モザイク喪失と関連している Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging
Takuro Kobayashi,Tsuyoshi Hachiya,Yan Lu,Yoshihiro Ikehata,Toshiyuki China,Haruna Kawano,Masayoshi Nagata,Hisamitsu Ide,Shuji Isotani,Shuko Nojiri,Takuro Iwami,Shunsuke Uchiyama,Yasushi Okazaki,Hidewaki Nakagawa,Takayuki Morisaki,Koichi Matsuda,Yoichiro Kamatani,Chikashi Terao & Shigeo Horie
npj Aging Published:29 July 2025
DOI:https://doi.org/10.1038/s41514-025-00261-w
Abstract
Mosaic loss of chromosome Y (mLOY) is the most common somatic mutation in hematopoietic cells of aging men and is linked to cancer risk and mortality. However, its relationship with treatment modalities remains unclear. In 348 prostate cancer patients at Juntendo University Hospital, local radiotherapy was associated with a higher prevalence of mLOY (OR = 2.55, 95% CI: 1.08–6.50, P = 0.04), whereas surgery and endocrine therapy were not. We then examined BioBank Japan data from over 30,000 patients with prostate, lung, colorectal, and gastric cancers. Fixed-effect meta-analysis across these sites showed a significant association between radiotherapy and mLOY (OR = 1.48, 95% CI: 1.11–1.98, P = 0.01). No significant effect heterogeneity was observed across cancer types (Q = 0.36, I² = 0%, P = 0.95). Our findings suggest that radiotherapy may exacerbate genomic instability, indicating a potential vulnerability in certain cancer patients to DNA damage induced by radiation therapy.
