2025-09-09 オックスフォード大学
<関連情報>
- https://www.ox.ac.uk/news/2025-09-09-new-ultrasound-helmet-enables-deep-brain-stimulation-people-without-surgery
- https://www.nature.com/articles/s41467-025-63020-1
ヒト深部脳回路の精密神経調節のための超音波システム Ultrasound system for precise neuromodulation of human deep brain circuits
Eleanor Martin,Morgan Roberts,Ioana F. Grigoras,Olivia Wright,Tulika Nandi,Sebastian W. Rieger,Jon Campbell,Tim den Boer,Ben T. Cox,Charlotte J. Stagg &Bradley E. Treeby
Nature Communications Published:05 September 2025
DOI:https://doi.org/10.1038/s41467-025-63020-1
Abstract
We introduce an advanced transcranial ultrasound stimulation (TUS) system for precise deep brain neuromodulation, featuring a 256-element helmet-shaped transducer array (555 kHz), stereotactic positioning, individualised planning, and real-time fMRI monitoring. Experiments demonstrated selective modulation of the lateral geniculate nucleus (LGN) and connected visual cortex regions. Participants showed significantly increased visual cortex activity during concurrent TUS and visual stimulation, with high cross-individual reproducibility. A theta-burst TUS protocol produced robust neuromodulatory effects, decreasing visual cortex activity for at least 40 min post-stimulation. Control experiments confirmed these effects were specific to the targeted LGN. Our findings reveal this system’s potential to non-invasively modulate deep brain circuits with unprecedented precision and specificity, offering new avenues for studying brain function and developing targeted therapies for neurological and psychiatric disorders, with transformative potential for both research and clinical applications.
