2025-11-19 ブラウン大学
<関連情報>
- https://www.brown.edu/news/2025-11-19/cannabis-alcohol
- https://psychiatryonline.org/doi/10.1176/appi.ajp.20250115
大麻のアルコール渇望と消費に対する急性効果:ランダム化比較クロスオーバー試験 Acute Effects of Cannabis on Alcohol Craving and Consumption: A Randomized Controlled Crossover Trial
Jane Metrik, Ph.D. jane_metrik@brown.edu, Elizabeth R. Aston, Ph.D., Rachel L. Gunn, Ph.D., Robert Swift, M.D., Ph.D., James MacKillop, Ph.D., and Christopher W. Kahler, Ph.D.
American Journal of Psychiatry Published:18 November 2025
DOI:https://doi.org/10.1176/appi.ajp.20250115
Abstract
Objective:
Cannabis use is strongly linked with heavy drinking and worse alcohol treatment outcomes; however, it may also contribute to decreased alcohol consumption. To date, no human studies have established a causal effect of cannabis on alcohol motivation. The aim of this double-blind crossover randomized clinical trial was to examine dose-dependent acute effects of delta-9-tetrahydrocannabinol (THC) on alcohol craving and consumption.
Methods:
Across three experimental days, 157 participants reporting heavy alcohol use and cannabis use two or more times weekly were randomized to smoke cannabis cigarettes containing 7.2% THC, 3.1% THC, or 0.03% THC (placebo), followed by exposures to neutral and personalized alcohol cues and an alcohol choice task for alcohol self-administration. A total of 138 participants completed two or more experimental sessions (mean age, 25.6 years [SD=5.1]; 35% women; 45% racial/ethnic minorities). Primary outcomes included craving, Alcohol Craving Questionnaire–Short Form, Revised (ACQ-SF-R), and an alcohol urge question; the secondary outcome was percent of total available milliliters of alcohol consumed.
Results:
There were no significant effects of cannabis on ACQ-SF-R ratings after smoking and during alcohol cue exposure, but 7.2% THC reduced alcohol urge immediately after smoking. Participants consumed significantly less alcohol after smoking cannabis with 3.1% THC and 7.2% THC, reducing consumption by 19% and 27%, respectively.
Conclusions:
Following overnight cannabis abstinence, smoking cannabis acutely decreased alcohol consumption compared to placebo. Further controlled research on a variety of cannabinoids is needed to inform clinical alcohol treatment guidelines.
