2025-12-02 ペンシルベニア州立大学(Penn State)
The team’s approach evaluates how AI-optimized MPCs influence the defensive immune system response to tumors, offering a highly personalized cancer treatment. The MPCs helped recruit immune cells, colored green in the figure, to infiltrate and help fight tumors, colored red in the figure. Credit: Provided by Pak Kin Wong. All Rights Reserved.
<関連情報>
- https://www.psu.edu/news/engineering/story/cancer-fighting-bacterial-product-cocktails-may-offer-personalized-treatment
- https://www.nature.com/articles/s41467-025-66238-1
個別化癌免疫療法のための微生物製品カクテル Microbial Product Cocktails for Personalized Cancer Immunotherapy
Yue Yan,Sijia Yang,Kathleen E. Mach,Guoli Chen,David J. DeGraff,Joseph C. Liao & Pak Kin Wong
Nature Communications Published:02 December 2025
DOI:https://doi.org/10.1038/s41467-025-66238-1
Abstract
The human immune system has evolved to interact with various commensal and pathogenic bacteria in intricate and nuanced ways. While the diversity of bacteria presents fundamental challenges in understanding immune-microbe interactions, it also offers ample opportunities for developing effective immunomodulatory therapies. Here we show microbial product cocktails as an alternative class of immunotherapy for cancer. Using freshly resected tumors from bladder cancer patients, an immuno-comparative analysis of recruitment and enhancement assay, and an artificial intelligence-guided optimization workflow, we establish a personalized platform for identifying potent microbial product cocktails that promote recruitment, infiltration, and activation of immune cells for cancer treatment. In an orthotopic mouse bladder cancer model, microbial product cocktails demonstrate immunoenhancement and improve survival rates compared with standard bacillus Calmette–Guérin immunotherapy.
