2023-03-15 ペンシルベニア州立大学(PennState)
最近の研究によると、タバコと大麻の共同曝露を受けた胎児は、中学校の時期に(9-12歳)非曝露児に比べて12倍の肥満リスクがあるという。しかし、この結果について他の要因が考慮されるべきであり、より多くの研究が必要であるとされている。
この研究は、ニューヨーク州西部の都市病院で出産前のケアを受けている妊婦を対象に行われ、肥満の発達の差異を調査した。研究者たちは、子供たちのBMIの軌跡の違いを検証し、子供たちを同様の人口統計学的特徴を持つ非曝露児と比較した。
今後、より多くの研究が必要であるが、この研究は妊娠中の物質曝露と肥満のリスクの関係を調査し、曝露による直接的な影響を解き明かすことを目的としている。
<関連情報>
- https://www.psu.edu/news/social-science-research-institute/story/prenatal-cigarette-cannabis-exposure-may-have-associations/
- https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13010
出生前のタバコと大麻の共同暴露と出生から小児期半ばまでの子供の肥満の発達について Prenatal tobacco and cannabis co-exposure and offspring obesity development from birth to mid-childhood
Kai Ling Kong, Jin-kyung Lee, Shannon Shisler, Panayotis K. Thanos, Marilyn A. Huestis, Larry Hawk, Rina D. Eiden
Pediatric Obesity Published: 03 February 2023
DOI:https://doi.org/10.1111/ijpo.13010
Summary
Background
Although the association between prenatal tobacco exposure and child obesity risk is well-established, less is known about co-exposure to tobacco and cannabis.
Objective
Determine the relation between prenatal substance co-exposure and obesity risk.
Methods
In a diverse sample of pregnant women, we examined the association between prenatal substance exposure (tobacco-only and co-exposure) and child BMI (kg/m2) trajectories from birth to mid-childhood (n = 262), overweight/obese status based on BMI percentiles from toddlerhood (24 months) to mid-childhood (9–12 years), and adiposity outcomes at mid-childhood (fat mass [kg], fat mass [%] and fat free mass [kg]; n = 128). Given that the major goal of this study was to examine the associations between prenatal substance exposure and child outcomes, we oversampled pregnant women for substance use (with tobacco as the primary focus).
Results
Multilevel models demonstrated that children in both exposure groups had a steeper increase in BMI trajectory from birth to mid-childhood and among co-exposed children, girls had a steeper increase than boys. Odds ratio of having obesity by mid-childhood was 12 times higher among those co-exposed than non-exposed. Co-exposure led to significantly greater fat mass and fat mass % compared with no exposure, but exposure to only tobacco was no different than no exposure.
Conclusions
Results highlight potentiating effects of cannabis exposure in the context of maternal tobacco use in pregnancy on obesity risk and the importance of multi-method assessments of obesity.
