2023-05-31 カロリンスカ研究所(KI)
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◆研究者は、認知症のない2568人の高齢者を追跡し、虚血性心疾患と認知機能の関連を調査した。今後の研究では、虚血性心疾患の発症後の認知経路や治療の影響をさらに探求する必要があるとされている。
<関連情報>
- https://news.ki.se/ischemic-heart-disease-linked-to-increased-risk-of-dementia
- https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13114
虚血性心疾患と認知機能低下および認知症の長期リスクとの関連性: コホート研究 Association of ischemic heart disease with long-term risk of cognitive decline and dementia: A cohort study
Yume Imahori, Davide L. Vetrano, Petter Ljungman, Erika J. Laukka, Jing Wu, Giulia Grande, Debora Rizzuto, Laura Fratiglioni, Chengxuan Qiu
Alzheimer’s & dementia Published: 30 May 2023
DOI:https://doi.org/10.1002/alz.13114
Abstract
INTRODUCTION
The independent and joint effect of ischemic heart disease (IHD) and coexisting atrial fibrillation (AF) and heart failure (HF) on dementia risk is largely unknown.
METHODS
This population-based cohort study included 2568 dementia-free participants (age ≥60 years) in SNAC-K, who were regularly examined from 2001–2004 through 2013–2016. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria. Global cognitive function was assessed using a global cognitive composite z-score derived from five cognitive domains. Data were analyzed using Cox, Fine-Gray, and linear mixed-effects models.
RESULTS
Overall, IHD at baseline was associated with multivariable-adjusted hazard ratio (HR) of 1.39 (95% confidence interval = 1.06-1.82) for dementia and multivariable-adjusted β-coefficient of -0.02 (-0.03 to -0.01) for annual changes in global cognitive z-score, independent of AF, HF, and cerebrovascular disease. Coexisting AF or HF did not add further risk to dementia and cognitive decline.
DISCUSSION
IHD is independently associated with dementia and cognitive decline in older adults, whereas coexisting AF/HF is not associated with an increased risk.
Highlights
- Is a history of ischemic heart disease (IHD) associated with a risk for dementia?
- How do coexisting heart diseases affect this association?
- IHD was an independent risk factor for dementia in older adults.
- This association was independent of coexisting heart and cerebrovascular diseases.
- The coexistence of heart diseases did not confer additional risk for dementia.
