2023-07-24 レンセラー工科大学 (RPI)
◆特に、オミクロン変異株に対しては他の変異株よりも効果的であり、他の抗ウイルス薬とは異なる作用機序を持っている可能性が示唆されています。しかし、現在は毒性の懸念からアメリカで承認されていないため、さらなる研究が必要です。スラミンなどのS-タンパク質結合を対象とする他の化合物は、COVID-19の治療法や予防法にさらに探求されるべきだと研究者は述べています。
<関連情報>
- https://news.rpi.edu/content/2023/07/24/100-year-old-treatment-inhibits-covid-19-infection
- https://www.nature.com/articles/s42003-023-04789-z
スラミンはスパイク蛋白質-ヘパラン硫酸とACE2レセプターの相互作用によりSARS-CoV-2の感染を阻害する。 Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions
Paul S. Kwon,Shirley Xu,Hanseul Oh,Seok-Joon Kwon,Andre L. Rodrigues,Maisha Feroz,Keith Fraser,Peng He,Fuming Zhang,Jung Joo Hong,Robert J. Linhardt & Jonathan S. Dordick
Communications Biology Published:08 April 2023
DOI:https://doi.org/10.1038/s42003-023-04789-z
Abstract
SARS-CoV-2 receptor binding domains (RBDs) interact with both the ACE2 receptor and heparan sulfate on the surface of host cells to enhance SARS-CoV-2 infection. We show that suramin, a polysulfated synthetic drug, binds to the ACE2 receptor and heparan sulfate binding sites on the RBDs of wild-type, Delta, and Omicron variants. Specifically, heparan sulfate and suramin had enhanced preferential binding for Omicron RBD, and suramin is most potent against the live SARS-CoV-2 Omicron variant (B.1.1.529) when compared to wild type and Delta (B.1.617.2) variants in vitro. These results suggest that inhibition of live virus infection occurs through dual SARS-CoV-2 targets of S-protein binding and previously reported RNA-dependent RNA polymerase inhibition and offers the possibility for this and other polysulfated molecules to be used as potential therapeutic and prophylactic options against COVID-19.
