2024-01-31 インペリアル・カレッジ・ロンドン(ICL)
◆心臓弁の置換手術は生命を救う治療法ですが、機械式と生体弁ともに医学的な欠点があります。ハーフィールド病院と帝国カレッジ・ロンドンの研究チームは、バイオデグラダブルポリマースキャフフォルドを使用し、体内で新しい組織を育てる生体弁を開発しました。
◆動物実験では、弁が6か月間機能し、細胞再生も観察されました。今後は動物実験を続け、組織再生プロセスをさらに詳しく調査し、約5年後に初の臨床試験を行う予定です。
<関連情報>
- https://www.imperial.ac.uk/news/250993/new-heart-treatment-helps-body-grow/
- https://www.nature.com/articles/s42003-023-05383-z
神経支配された生きた肺根の弁形成が細胞足場によって誘導される Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
Magdi H. Yacoub,Yuan-Tsan Tseng,Jolanda Kluin,Annemijn Vis,Ulrich Stock,Hassiba Smail,Padmini Sarathchandra,Elena Aikawa,Hussam El-Nashar,Adrian H. Chester,Nairouz Shehata,Mohamed Nagy,Amr El-sawy,Wei Li,Gaetano Burriesci,Jacob Salmonsmith,Soha Romeih & Najma Latif
Communications Biology Published:07 October 2023
DOI:https://doi.org/10.1038/s42003-023-05383-z
Abstract
Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”.
