溶連菌A型感染の世界的急増に関する新たな洞察(Analysis reveals new insights into global surge of Strep A infections)

2024-05-10 インペリアル・カレッジ・ロンドン(ICL)

<関連情報>

• https://www.imperial.ac.uk/news/253233/analysis-reveals-insights-into-global-surge/
• https://www.nature.com/articles/s41467-024-47929-7

パンデミック後の英国で急増した化膿レンサ球菌M1UKの急速な拡大と国際的拡散 Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes

Ana Vieira,Yu Wan,Yan Ryan,Ho Kwong Li,Rebecca L. Guy,Maria Papangeli,Kristin K. Huse,Lucy C. Reeves,Valerie W. C. Soo,Roger Daniel,Alessandra Harley,Karen Broughton,Chenchal Dhami,Mark Ganner,Marjorie A. Ganner,Zaynab Mumin,Maryam Razaei,Emma Rundberg,Rufat Mammadov,Ewurabena A. Mills,Vincenzo Sgro,Kai Yi Mok,Xavier Didelot,Nicholas J. Croucher,… Shiranee Sriskandan
Nature Communications  Published:10 May 2024
DOI:https://doi.org/10.1038/s41467-024-47929-7

Abstract

The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1_UK to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1_global strains, invasive M1_UK strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes covRS. The emergence of M1_UK is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1_UK clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1_UK isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1_UK point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.