泳ぐマイクロロボットがマウスの転移性肺腫瘍に癌と闘う薬を届ける(Swimming Microrobots Deliver Cancer-fighting Drugs to Metastatic Lung Tumors in Mice)

ad

2024-06-12 カリフォルニア大学サンディエゴ校(UCSD)

カリフォルニア大学サンディエゴ校の技術者が、肺内を泳ぎ回って癌治療薬を転移性腫瘍に直接届けることができる微小ロボット(マイクロロボット)を開発しました。このアプローチは、マウスの実験で腫瘍の成長と拡散を抑え、生存率を向上させることが示されました。研究結果は6月12日にScience Advances誌に発表されました。マイクロロボットは、薬剤を充填したナノ粒子を緑藻細胞に付着させたもので、ナノ粒子は化学療法薬ドキソルビシンを含む生分解性ポリマーでできており、赤血球膜で覆われています。この膜が免疫系からナノ粒子を保護し、肺内での薬剤効果を高めます。研究チームは次に、この治療法を大動物や最終的には人間での臨床試験に進めることを目指しています。

<関連情報>

バイオハイブリッドマイクロロボットが薬剤入りナノ粒子を局所的かつ能動的に送達し、肺転移の進行を抑制する Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis

FANGYU ZHANG, ZHONGYUAN GUO, ZHENGXING LI, HAO LUAN, […], AND JOSEPH WANG
Science Advances  Published:12 Jun 2024
DOI:https://doi.org/10.1126/sciadv.adn6157

泳ぐマイクロロボットがマウスの転移性肺腫瘍に癌と闘う薬を届ける(Swimming Microrobots Deliver Cancer-fighting Drugs to Metastatic Lung Tumors in Mice)

Abstract

Lung metastasis poses a formidable challenge in the realm of cancer treatment, with conventional chemotherapy often falling short due to limited targeting and low accumulation in the lungs. Here, we show a microrobot approach using motile algae for localized delivery of drug-loaded nanoparticles to address lung metastasis challenges. The biohybrid microrobot [denoted “algae-NP(DOX)-robot”] combines green microalgae with red blood cell membrane–coated nanoparticles containing doxorubicin, a representative chemotherapeutic drug. Microalgae provide autonomous propulsion in the lungs, leveraging controlled drug release and enhanced drug dispersion to exert antimetastatic effects. Upon intratracheal administration, algae-NP(DOX)-robots efficiently transport their drug payload deep into the lungs while maintaining continuous motility. This strategy leads to rapid drug distribution, improved tissue accumulation, and prolonged retention compared to passive drug-loaded nanoparticles and free drug controls. In a melanoma lung metastasis model, algae-NP(DOX)-robots exhibit substantial improvement in therapeutic efficacy, reducing metastatic burden and extending survival compared to control groups.

急性細菌性肺炎を治療するための生体内抗生物質デリバリーのためのナノ粒子修飾マイクロロボット Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia

Fangyu Zhang,Jia Zhuang,Zhengxing Li,Hua Gong,Berta Esteban-Fernández de Ávila,Yaou Duan,Qiangzhe Zhang,Jiarong Zhou,Lu Yin,Emil Karshalev,Weiwei Gao,Victor Nizet,Ronnie H. Fang,Liangfang Zhang & Joseph Wang
Nature Materials  Published:22 September 2022
DOI:https://doi.org/10.1038/s41563-022-01360-9

extended data figure 1

Abstract

Bioinspired microrobots capable of actively moving in biological fluids have attracted considerable attention for biomedical applications because of their unique dynamic features that are otherwise difficult to achieve by their static counterparts. Here we use click chemistry to attach antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles to natural microalgae, thus creating hybrid microrobots for the active delivery of antibiotics in the lungs in vivo. The microrobots show fast speed (>110 µm s-1) in simulated lung fluid and uniform distribution into deep lung tissues, low clearance by alveolar macrophages and superb tissue retention time (>2 days) after intratracheal administration to test animals. In a mouse model of acute Pseudomonas aeruginosa pneumonia, the microrobots effectively reduce bacterial burden and substantially lessen animal mortality, with negligible toxicity. Overall, these findings highlight the attractive functions of algae–nanoparticle hybrid microrobots for the active in vivo delivery of therapeutics to the lungs in intensive care unit settings.

医療・健康
ad
ad
Follow
ad
タイトルとURLをコピーしました