汗で病気マーカーのレベルを測定する健康モニター(Sweat health monitor measures levels of disease markers)

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2024-06-20 ワシントン州立大学(WSU)

ワシントン州立大学の研究者が開発したウェアラブル健康モニターは、運動中の汗中の重要な生化学物質のレベルを正確に測定できます。この3Dプリントモニターは、糖尿病、痛風、腎臓病、心臓病などの一般的な病気の診断を簡便かつ非侵襲的に行う可能性があります。研究チームは、ボランティアの運動中にグルコース、乳酸、尿酸のレベルと発汗率を正確にモニタリングしました。3Dプリント技術を用いて、一段階の製造プロセスでモニターを作成し、単原子触媒と酵素反応を用いて信号を増強しました。研究者は、今後デバイス設計の改善と商業化を目指しています。

<関連情報>

その場での発汗分析とバイオマーカー検出のための3Dプリントされた柔軟なマイクロ流体ヘルスモニター 3D-Printed Flexible Microfluidic Health Monitor for In Situ Sweat Analysis and Biomarker Detection

Chuchu Chen, Yonghao Fu, Sonja S. Sparks, Zhaoyuan Lyu, Arijit Pradhan, Shichao Ding, Narasimha Boddeti, Yun Liu, Yuehe Lin, Dan Du, and Kaiyan Qiu
ACS Sensors  Published:May 31, 2024
DOI:https://doi.org/10.1021/acssensors.4c00528

Abstract

汗で病気マーカーのレベルを測定する健康モニター(Sweat health monitor measures levels of disease markers)

Wearable sweat biosensors have shown great progress in noninvasive, in situ, and continuous health monitoring to demonstrate individuals’ physiological states. Advances in novel nanomaterials and fabrication methods promise to usher in a new era of wearable biosensors. Here, we introduce a three-dimensional (3D)-printed flexible wearable health monitor fabricated through a unique one-step continuous manufacturing process with self-supporting microfluidic channels and novel single-atom catalyst-based bioassays for measuring the sweat rate and concentration of three biomarkers. Direct ink writing is adapted to print the microfluidic device with self-supporting structures to harvest human sweat, which eliminates the need for removing sacrificial supporting materials and addresses the contamination and sweat evaporation issues associated with traditional sampling methods. Additionally, the pick-and-place strategy is employed during the printing process to accurately integrate the bioassays, improving manufacturing efficiency. A single-atom catalyst is developed and utilized in colorimetric bioassays to improve sensitivity and accuracy. A feasibility study on human skin successfully demonstrates the functionality and reliability of our health monitor, generating reliable and quantitative in situ results of sweat rate, glucose, lactate, and uric acid concentrations during physical exercise.

医療・健康
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