母親の自殺: 周産期死亡を取り巻く複雑な要因に関する洞察を提供(Maternal suicide: U-M study provides insights into complicating factors surrounding perinatal deaths)

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2024-06-27 ミシガン大学

ミシガン大学の研究者によると、妊娠中および出産後の自殺は米国で主要な死因であり、多くの死は予防可能です。JAMA Network Openに発表された新しい研究では、周産期自殺の状況とその変化をCDCのデータを用いて分析しました。研究では、精神健康問題、物質使用、親密なパートナーの問題が重要な誘因であることが判明しました。研究は妊娠中または出産後1年以内に自殺した1,100人以上の女性のデータと、過去1年に妊娠していない女性17,600人以上のデータを比較しました。研究者は、精神健康、物質使用、親密なパートナーの問題に対する政策と実践が、周産期自殺リスクの削減に必要であると強調しています。

<関連情報>

周産期における自殺死亡率 Suicide Mortality During the Perinatal Period

Kara Zivin, PhD, MS, MA, MFA; Chuwen Zhong, MPH; Alejandro Rodríguez-Putnam, MPH; et al
JAMA Network Open  Published:June 27, 2024
DOI:10.1001/jamanetworkopen.2024.18887

Study Flowchart

Key Points

Question What circumstances are associated with perinatal (ie, pregnant and postpartum) suicide, and how do they vary across the perinatal period?

Findings In this cross-sectional study using data from the National Violent Death Reporting System, perinatal decedents were more likely to experience intimate partner problems (IPPs), depressed mood, substance abuse, physical health problems, and recent bereavement compared with matched nonperinatal decedents. Qualitative analysis identified precipitating mental health circumstances, including postpartum depression.

Meaning These findings highlight the need for policy making that targets mental health, substance use, and IPPs to mitigate perinatal suicide risk.

Abstract

Importance The US has the highest maternal mortality rate among developed countries. The Centers for Disease Control and Prevention deems nearly all of these deaths preventable, especially those attributable to mental health conditions. Coordination between US health care and social service systems could help further characterize circumstances and risks associated with perinatal suicide mortality.

Objective To examine contextual and individual precipitating circumstances and risks associated with perinatal suicide.

Design, Setting, and Participants This cross-sectional observational study used a convergent mixed methods design to explore factors contributing to maternal suicides and deaths of undetermined intent (hereinafter, undetermined deaths) identified in National Violent Death Reporting System (NVDRS) data for January 1, 2003, to December 31, 2021. Analyses included decedents who were aged 10 to 50 years and pregnant or post partum at death (collectively, the perinatal group) and demographically matched female decedents who were not pregnant or recently pregnant (nonperinatal group) at death. Analyses were performed between December 2022 and December 2023.

Exposures Pregnancy status at death (perinatal or nonperinatal).

Main Outcomes and Measures The main outcomes included contributing circumstances associated with suicides and undetermined deaths cited in coroner, medical examiner, or law enforcement case narratives. The study examined quantitative differences between groups using a matched analysis and characterized key themes of salient suicide circumstances using qualitative content analysis.

Results This study included 1150 perinatal decedents identified in the NVDRS: 456 (39.6%) were pregnant at death, 203 (17.7%) were pregnant within 42 days of death, and 491 (42.7%) were pregnant within 43 to 365 days before death, yielding 694 postpartum decedents. The nonperinatal comparison group included 17 655 female decedents aged 10 to 50 years. The mean (SD) age was 29.1 (7.4) years for perinatal decedents and 35.8 (10.8) years for nonperinatal decedents. Compared with matched nonperinatal decedents, perinatal decedents had higher odds of the following identified contributing circumstances: intimate partner problems (IPPs) (odds ratio [OR], 1.45 [95% CI, 1.23-1.72]), recent argument (OR, 1.33 [95% CI, 1.09-1.61]), depressed mood (OR, 1.39 [95% CI, 1.19-1.63]), substance abuse or other abuse (OR, 1.21 [95% CI, 1.03-1.42]), physical health problems (OR, 1.37 [95% CI, 1.09-1.72]), and death of a family member or friend (OR, 1.47 [95% CI, 1.06-2.02]). The findings of the qualitative analysis emphasized the importance of mental health and identified 128 decedents (12.4%) with postpartum depression.

Conclusions and Relevance This study provides insights into complex factors surrounding maternal suicide, and it highlights opportunities for further research to understand long-term consequences of perinatal mental health. These findings also underscore the need for targeted evidence-based interventions and effective policies targeting mental health, substance use, and IPPs to prevent maternal suicide and enhance maternal health outcomes.

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