2004-07-29 カリフォルニア大学サンディエゴ校(UCSD)
UCサンディエゴ主導の研究チームが、ウェアラブルで非侵襲的なデバイスを用いて臨床環境で人間の頸神経活動を測定できることを初めて実証しました。このデバイスは、自律神経活動(ANG)を記録し、特に迷走神経や頸動脈洞神経などの活動を捉えます。迷走神経は、消化、心拍数、免疫システムに影響を与える重要な役割を果たします。
◆このデバイスは、インフルエンザなどの病原体感染や炎症を早期に検出するために設計されており、臨床での実用化を目指しています。研究チームは、細菌由来の毒素で人工的に炎症を引き起こした被験者の頸部にデバイスを装着し、神経活動の変化と炎症性タンパク質の放出を追跡しました。この技術は、早期の敗血症検出や治療効果の評価、 PTSDなどの精神的健康状態の理解に役立つ可能性があります。研究は「Nature Communications Biology」に掲載されました。
<関連情報>
- https://today.ucsd.edu/story/uc-san-diego-researchers-use-non-invasive-technique-to-record-involuntary-human-nervous-system
- https://www.nature.com/articles/s42003-024-06435-8
- https://www.nature.com/articles/s41598-022-21817-w
生体内リポ多糖誘発炎症の代理としての非侵襲的腹側頸部磁気神経写真法 Non-invasive ventral cervical magnetoneurography as a proxy of in vivo lipopolysaccharide-induced inflammation
Yifeng Bu,Jamison Burks,Kun Yang,Jacob Prince,Amir Borna,Christopher L. Coe,Alan Simmons,Xin M. Tu,Dewleen Baker,Donald Kimball,Ramesh Rao,Vishal Shah,Mingxiong Huang,Peter Schwindt,Todd P. Coleman & Imanuel Lerman
Nature Biology Published:29 July 2024
DOI:https://doi.org/10.1038/s42003-024-06435-8
Abstract
Maintenance of autonomic homeostasis is continuously calibrated by sensory fibers of the vagus nerve and sympathetic chain that convey compound action potentials (CAPs) to the central nervous system. Lipopolysaccharide (LPS) intravenous challenge reliably elicits a robust inflammatory response that can resemble systemic inflammation and acute endotoxemia. Here, we administered LPS intravenously in nine healthy subjects while recording ventral cervical magnetoneurography (vcMNG)-derived CAPs at the rostral Right Nodose Ganglion (RNG) and the caudal Right Carotid Artery (RCA) with optically pumped magnetometers (OPM). We observed vcMNG RNG and RCA neural firing rates that tracked changes in TNF-α levels in the systemic circulation. Further, endotype subgroups based on high and low IL-6 responders segregate RNG CAP frequency (at 30-120 min) and based on high and low IL-10 response discriminate RCA CAP frequency (at 0-30 min). These vcMNG tools may enhance understanding and management of the neuroimmune axis that can guide personalized treatment based on an individual’s distinct endophenotype.
逐次的自律神経ストレス負荷時の頸部電気神経図が可能な柔軟な粘着性表面電極アレイ A flexible adhesive surface electrode array capable of cervical electroneurography during a sequential autonomic stress challenge
Yifeng Bu,Jonas F. Kurniawan,Jacob Prince,Andrew K. L. Nguyen,Brandon Ho,Nathan L. J. Sit,Timothy Pham,Vincent M. Wu,Boris Tjhia,Andrew J. Shin,Tsung-Chin Wu,Xin M. Tu,Ramesh Rao,Todd P. Coleman & Imanuel Lerman
Scientific Reports Published:14 November 2022
DOI:https://doi.org/10.1038/s41598-022-21817-w
Abstract
This study introduces a flexible, adhesive-integrated electrode array that was developed to enable non-invasive monitoring of cervical nerve activity. The device uses silver-silver chloride as the electrode material of choice and combines it with an electrode array consisting of a customized biopotential data acquisition unit and integrated graphical user interface (GUI) for visualization of real-time monitoring. Preliminary testing demonstrated this electrode design can achieve a high signal to noise ratio during cervical neural recordings. To demonstrate the capability of the surface electrodes to detect changes in cervical neuronal activity, the cold-pressor test (CPT) and a timed respiratory challenge were employed as stressors to the autonomic nervous system. This sensor system recording, a new technique, was termed Cervical Electroneurography (CEN). By applying a custom spike sorting algorithm to the electrode measurements, neural activity was classified in two ways: (1) pre-to-post CPT, and (2) during a timed respiratory challenge. Unique to this work: (1) rostral to caudal channel position-specific (cephalad to caudal) firing patterns and (2) cross challenge biotype-specific change in average CEN firing, were observed with both CPT and the timed respiratory challenge. Future work is planned to develop an ambulatory CEN recording device that could provide immediate notification of autonomic nervous system activity changes that might indicate autonomic dysregulation in healthy subjects and clinical disease states.
