重度の Covid の予防にテストステロンが果たす役割を専門家がさらに証明(Experts provide further proof of role testosterone plays in preventing severe Covid)

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2024-08-09 スウォンジー大学

重度の Covid の予防にテストステロンが果たす役割を専門家がさらに証明(Experts provide further proof of role testosterone plays in preventing severe Covid)

スウォンジー大学の研究者を含むチームが、新たに発表された研究で、性ホルモンがCovid-19の重症度に影響を与える可能性があることを示した。特に、低テストステロンが高齢男性の炎症反応を増加させ、Covid-19の予後を悪化させる可能性があるとされる。研究は、入院患者と対照群の指の長さの違い(デジット比、Digit Ratio)を調査し、入院患者は低テストステロンに関連する短い小指を持つことが判明した。これにより、テストステロンがCovid-19の重症化を防ぐ可能性が示唆された。

<関連情報>

COVID-19 の桁数比と入院: COVID-19重症度に関する低アンドロゲン主導説と高アンドロゲン主導説の検証 Digit ratios and hospitalization for COVID-19: A test of the low-androgen-driven and high-androgen-driven theories of COVID-19 severity

Anna Kasielska-Trojan, John T. Manning, Maciej Jabłkowski, Jolanta Białkowska-Warzecha, Oliwia Kwaśniewska, Angelica L Hirschberg, Bogusław Antoszewski
Andrology  Published: 29 July 2024
DOI:https://doi.org/10.1111/andr.13709

Abstract

Background
Sex hormones are likely to be important determinants of COVID-19 severity, and two opposing explanations regarding severity, the low-androgen-driven and high-androgen-driven theories, seek to explain this pattern. Digit ratios are sex dependent (males < females) and are claimed to be markers for both prenatal and postnatal testosterone.

Objectives
Here, we use a measure of COVID-19severity (hospitalization), compare digit ratios in patients and controls and consider whether vaccination status changed these associations.

Material and methods
Four digits were measured (2D, 3D, 4D, 5D). There were 194 participants (94 hospitalized patients [45 men] and 100 controls [53 men]) in Sample I and 162 participants (100 hospitalized [42 men], including 40 vaccinated and 62 controls [32 men]) in Sample II. Six ratios were calculated (2D:3D; 2D:4D; 2D:5D; 3D:4D; 3D:5D, 4D:5D) and compared between COVID-19 hospitalized and non-hospitalized patients and vaccinated and non-vaccinated.

Results
In comparison to controls, we found higher (“feminized”) means in patient ratios that included 5D (2D:5D; 3D:5D; 4D:5D) in both samples. The differences were independent of sex and age. Hospitalized patients with COVID-19 have higher (feminized) means and higher standard deviations (SDs) for 5D digit ratios.

Discussion
Digit ratios are sex dependent (males < females) and are considered as markers for both prenatal and postnatal testosterone. If verified in future studies, the results will be helpful in regard to targeting mortality-reducing therapies for COVID-19 in certain groups of patients.

Conclusion
We conclude that the association between high (feminized) 5D ratios and hospitalization supports the low-androgen-driven theory of COVID-19 severity.

医療・健康
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