2024-08-13 ノースカロライナ州立大学(NCState)
<関連情報>
- https://news.ncsu.edu/2024/08/ultrasound-diagnostic-parameters/
- https://www.nature.com/articles/s41598-024-66390-6
肺の定量的超音波検査による間質性肺疾患の病期分類とモニタリング Lung quantitative ultrasound to stage and monitor interstitial lung diseases
Azadeh Dashti,Roshan Roshankhah,Theresa Lye,John Blackwell,Stephanie Montgomery,Thomas Egan,Jonathan Mamou & Marie Muller
Scientific Reports Published:16 July 2024
DOI:https://doi.org/10.1038/s41598-024-66390-6
Abstract
Chronic interstitial lung diseases (ILDs) require frequent point-of-care monitoring. X-ray-based methods lack resolution and are ionizing. Chest computerized tomographic (CT) scans are expensive and provide more radiation. Conventional ultrasound can detect severe lung damage via vertical artifacts (B-lines). However, this information is not quantitative, and the appearance of B-lines is operator- and system-dependent. Here we demonstrate novel ultrasound-based biomarkers to assess severity of ILDs. Lung alveoli scatter ultrasound waves, leading to a complex acoustic signature, which is affected by changes in alveolar density due to ILDs. We exploit ultrasound scattering in the lung and combine quantitative ultrasound (QUS) parameters, to develop ultrasound-based biomarkers that significantly correlate (p = 1e-4 for edema and p = 3e-7 for fibrosis) to the severity of pulmonary fibrosis and edema in rodent lungs. These innovative QUS biomarkers will be very significant for monitoring severity of chronic ILDs and response to treatment, especially in this new era of miniaturized and highly portable ultrasound devices.
