2024-10-10 カリフォルニア大学リバーサイド校(UCR)
<関連情報>
- https://news.ucr.edu/articles/2024/10/10/how-your-skin-tone-could-affect-your-meds
- https://link.springer.com/article/10.1186/s40246-024-00677-7
ヒトの祖先の違いによる薬物反応のばらつきを予測するための色素沈着皮膚モデルの実装 Implementing differentially pigmented skin models for predicting drug response variability across human ancestries
Sophie Zaaijer & Simon C. Groen
Human Genomics Published:09 October 2024
DOI:https://doi.org/10.1186/s40246-024-00677-7
Abstract
Persistent racial disparities in health outcomes have catalyzed legislative reforms and heightened scientific focus recently. However, despite the well-documented properties of skin pigments in binding drug compounds, their impact on therapeutic efficacy and adverse drug responses remains insufficiently explored. This perspective examines the intricate relationships between variation in melanin-based skin pigmentation and pharmacokinetics and -dynamics, highlighting the need for considering diversity in skin pigmentation as a variable to advance the equitability of pharmacological interventions. The article provides guidelines on the selection of New Approach Methods (NAMs) to foster inclusive study designs in preclinical drug development pipelines, leading to an improved level of translatability to the clinic.
