2025-04-10 マックス・プランク研究所
<関連情報>
- https://www.mpg.de/24488401/0407-vasb-detection-of-neural-stem-cells-outside-the-brain-154090-x
- https://www.nature.com/articles/s41556-025-01641-w
神経上皮に由来する多能性神経幹細胞がマウスの中枢神経系外に存在することを発見 Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system
Dong Han,Wan Xu,Hyun-Woo Jeong,Hongryeol Park,Kathrin Weyer,Yaroslav Tsytsyura,Martin Stehling,Guangming Wu,Guocheng Lan,Kee-Pyo Kim,Henrik Renner,Dong Wook Han,Yicong Chen,Daniela Gerovska,Marcos J. Araúzo-Bravo,Jürgen Klingauf,Jens Christian Schwamborn,Ralf H. Adams,Pentao Liu & Hans R. Schöler
Nature Cell Biology Published:10 April 2025
DOI:https://doi.org/10.1038/s41556-025-01641-w
Abstract
Conventional understanding dictates that mammalian neural stem cells (NSCs) exist only in the central nervous system. Here, we report that peripheral NSCs (pNSCs) exist outside the central nervous system and can be isolated from mouse embryonic limb, postnatal lung, tail, dorsal root ganglia and adult lung tissues. Derived pNSCs are distinct from neural crest stem cells, express multiple NSC-specific markers and exhibit cell morphology, self-renewing and differentiation capacity, genome-wide transcriptional profile and epigenetic features similar to control brain NSCs. pNSCs are composed of Sox1+ cells originating from neuroepithelial cells. pNSCs in situ have similar molecular features to NSCs in the brain. Furthermore, many pNSCs that migrate out of the neural tube can differentiate into mature neurons and limited glial cells during embryonic and postnatal development. Our discovery of pNSCs provides previously unidentified insight into the mammalian nervous system development and presents an alternative potential strategy for neural regenerative therapy.
